Acute and Sub-acute Oral Toxicity of Hydroethanolic Root Extract of Annona stenophylla Engl. and Diels in Sprague Dawley Rats 期刊名称： Journal of Biologically Active Products from Nature
作者： Chagonda, Lameck S., Tafadzwa, Munodawafa, Dexter, Tagwirei, Louis,
Gadaga, Exnevia, Gomo, Felicity, Bierman, Tapiwa, Siziba爱护草坪的宣传语
张信哲信仰歌词年份： 2015年
期号： 第5期
关于英文关键词： Annona stenophylla Engl. and Diels;acute and sub-acute
toxicity;Sprague Dawley rats;clinical and histopathological changes
摘要：The acute and sub-acute oral toxicity of the hydroethanolic root extract of Annona stenophylla Engl. and Diels in Sprague Dawley rats was determined by administering the crude extract daily in the range 2502000 mg/kg body weight and the animals examined for physical, histopathological and clinic
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高宇同al biochemistry changes. There were no behavioural changes or deaths in the acute toxicity tests up to 2000 mg/kg b. wt over 14 days. There were no major changes in the clinical biochemistry parameters measured: Alanine aminotransfera (ALT), Aspartate amino transfera (AST), Alkaline phosphata (ALP), Gamma-glutamyl transfera (GGT), gluco, creatinine and total bilirubin (p>0.05) and in the histopathological tissue ctions of the pancreas and liver compared with the control rats in the sub-acute tests over 28 days. The
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