Nuclear receptor subfamily 4, group A, member 1 inhibits extrinsic apoptosis and reduces caspa-8 activity in H2O2-induced human HUC-F2 fibroblasts.
期刊名称： Redox Report
学生检讨书格式作者： Yuri Shimizu,Reiko Miyakura,Yuzuru Otsuka
象征造句
凤凰205年份： 2015年
期号： 第2期心情有哪些
关键词： NR4A1;Apoptosis;Caspa-8;Oxidative stress
摘要：Objective: Apoptosis is characterized by distinct morphological and biochemical changes that occur upon activation of a family of rine proteas
known as caspas. Reactive oxygen species (ROS) induce apoptosis in many cell
systems. Nuclear receptor subfamily 4, group A, member 1 (NR4A1) has been
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shown to induce apoptosis in a number of cell lineages, but can also paradoxically act as a death inhibitory factor. In the current study, we focud on the potential
role of NR4A1 in hydrogen peroxide (H2O2)-induced apoptosis of normal human
鱼系umbilical cord fibroblast (HUC-F2) cells.
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