Cancer stem cell and cancer stemloids: From biology国学学习
to therapy
期刊名称： Cancer Biology & Therapy
作者： Blagosklonny,Mikhail V
病字头一个山>黑枸杞泡酒的功效年份： 2007年
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期号： 第11期
关键词： Animals;Humans;Teratogens;Drug Resistance, Neoplasm;Cell
Proliferation;Cell Line, Tumor;Neoplastic Stem Cells;Neoplasms
摘要：It has become a clich that cancer therapy fails becau it does not target rare cancer stem cells (CSCs). Here we discuss that this is not how therapy fails and not any cancer cell with stem-like properties is CSC. Paradoxically, CSCs must be resting to explain their resistance to therapy yet must
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be cycling to explain their persistence in cell culture. To solve contradictions, this article introduces the term cancer stemloids (or stem cell-like cells) to describe proliferating lf-renewing cells. The stem cell hierarchy (stem proliferating terminal cells) exists exactly to parate lf-renewal (immortality) from proliferation. Cancer stemloids break the stem cell hierarchy and eventually may replace other cells. While CSC is shielded蒜蓉茼蒿的家常做法
from any lective pressure and therefore unable to drive tumor progression,
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