Enterovirus 71 mediates cell cycle arrest in S pha through non-structural protein 3D 期刊名称： Cell Cycle
作者： Yu, Jinghua,Zhang, Liying,Ren, Peiyou,Zhong, Ting,Li, Zhaolong,Wang,
Zengyan,Li, Jingliang,Liu, Xin,Zhao, Ke,Zhang, Wenyan,Yu, Xiao-Fang
年份： 2015年
海鲜煲的做法期号： 第3期
关键词： cell cycle arrest; enterovirus 71 (EV71); polymera 3D; viral replication为什么越吃越饿
摘要：Many virus disrupt the host cell cycle to facilitate their own growth. We assd the mechanism and function of enterovirus 71 (EV71), a primary causative agent for recent hand, foot, and mouth dia outbreaks, in manipulating cell cycle progression. Our results suggest that EV71 infection induces S-pha arrest in diver cell types by preventing the cell cycle transition from the S pha into the和月亮有关的诗句
图书的种类G2/M pha. Similar results were obrved for an alternate picornavirus, Coxsackievirus A16. Synchronization in S pha, but not G0/G1 pha or G2/M pha, promotes viral replication. Consistent with its ability to arrest cells in S pha, the expression of cyclin A2, CDK 2, cyclin E1, and cyclin B1 was regulated by EV71 through increasing transcription of cyclin E1, promoting proteasome-mediated degradation of cyclin A2
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