李世民怎么死的专利名称：Novel phthalazinone derivatives, as Aurora-a kina inhibitors
芦苇节
发明人：EDWARD BOYD,SABINE
怎么进注册表HUENSCH,WOLFGANG VON DER
SAAL,JUSTIN WARNE,MATTHIAS
RUETH,BERNHARD GOLLER,STEFAN
WEIGAND,STEFAN SCHEIBLICH,GUY野棉花
GEORGES,FREDERICK BROOKFIELD,PETRA
求学的成语
RUEGER,CHRISTINE SCHUELL
独居的一年申请号：AU2005287458
申请日：20050923
公开号：AU2005287458A1
公开日：
内存和储存的区别20060330
安中片
专利内容由知识产权出版社提供
摘要：Obtaining the above-mentioned Compounds, medicinal products containing them and their manufacture, as well as the u of the above-mentioned compounds in the control or prevention of illness such as cancer.Claim 1: a compound of the formula (1) wherein R1, R3 and R4 RF2, Independence between mean R8 X - - - - - heterociclil cicloalquil T1, T2 -, h, halogen, Nitro, cyano, - Oh, - NH2, - C (o) Oh, - C (o) NH2, - S (o) 2nh2, NHC (NH2) -, - C (o) NH - or alkyl, - C (o) (alkyl) - n
or - alkyl - NHC (o) NH - or - alqui The NHC, (OR) n - (alkyl) - alkyl - or - S (o) 2nh - o-alkyl,S (o) 2n - (alkyl) - or - alkyl or alkyl, optionally substituted once or veral times by Halogen, Hydroxy or alkoxy; R8 is cicloalquil heterociclil - T2 - T1 - T3 -, aryl, heteroaryl or optionally substituted alkyl - T4 -once or veral times by Halogen, X is - C (o) NH -, - C (o) n (alkyl) - N - (alkyl) -, - C (o)
(NHC (o) -, - NH - NHC (OR), (OR) - NHC (alkyl) - N - (or OC) - (alkyl) - N - (or NHS) 2 - (OR) 2nh, - S, - S (o) 2N (alkyl) -,2 - (OR) - S, - S (o) -, - C (o) o -, OC (o) -, - C (o) -, - NH -, N - (alkyl) -, - or - or - S -, and T1, T2, T3 and T4 with Independence between mean a simple link or alquileno optionally replaced once or twice by Hydroxy; R5 is H, alkyl, optionally substituted by Halogen or veral times, heteroa Rilo or phenyl, which is optionally substituted by Halogen once or twice, NO2 -, - Oh, - C (o) o- C (o) nH aryl -, - C (o) NH2, - C (o) nH alkyl, - C (o) n (alkyl) 2, - C (o) - heterociclilo, - NH2, - NHC (or aryl) - - (OR) - NHC, cycloalkyl, - NHC (OR) - alkyl - NHC (or alkoxyalkyl esters) -, - NH - S (or aryl) 2 -, - NH - S (o) 2 - alkyl, - C (o) NH - S (or aryl) 2 -, - C (o) NH (2) - S - I - S (o) 2 - alkyl, alkyl, alkoxy or alquilsulfanilo, dic Hos alkyl groups,And are alquilsulfanilo alkoxy optionally substituted by Halogen once or veral times; 1,3 dihydro - isobenzofuranilo, benzo [1.3] [- 5 - ILO, cycloalkyl or alquenilo; and is alquileno, alquileno - C (o) - or alquileno - ch (OH) -; n is 0 OR 1; R6 is H, alkyl halogeno, cyano or; R7 is H, alkyl or cicloalqu ILO; and pharmaceutically acceptable salts of the sam
e.Claim 1, a process for the production of the compounds of formula (1), in which (a) REACT with the compound of formula (1) wherein R1, R2, R3, R4, R5 and and have the meanings defined in claim 1 above, with a compound of formula (3), in which R6 and R7 have the meanings defined in claim 1,To obtain the corresponding Compound of the formula (1); (b) Isolating The Compound of the formula (1) of the reactive mixture, and (c) if desired, turns into a pharmaceutically acceptable Salt.
申请人：F. HOFFMANN-LA ROCHE AG
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