维吾尔药艾克热布蜜膏与散剂溶出度比较

更新时间:2023-05-17 08:21:33 阅读: 评论:0

凉拌苦瓜怎么做维吾尔药艾克热布蜜膏与散剂溶出度比较
目的 建立艾克热布蜜膏中胡椒碱溶出度的测定方法,考察蜜膏与散剂中胡椒碱的溶出度情况。 方法 采用高效液相色谱法进行含量测定,色谱条件为Fusion-RP C18(4.6 mm×250 mm,4 μm),流动相为甲醇-水(65草儿∶数字035),检测波长为343 nm,流速为1.0 mL/min;以胡椒碱累积溶出率为考察指标,筛选溶出度测定条件,计算胡椒碱的累积溶出率。 结果 溶出度测定条件为桨法,转速100 r/min,以纯水为溶出介质。蜜膏剂中胡椒碱在60 min时溶出达90%,120 min时几乎全部溶出。散剂中胡椒碱在60 min时溶出60%,120 min时溶出90%。 结论 散剂中胡椒碱较蜜膏剂溶出度速度快。
楚简[Abstract] Objective To establish the dissolution method of piperine in Aikerebu majun and rearch the dissolution behavior of piperine in Aikerebu Majun and Powders. Methods The content of piperine was determined by HPLC method. The Fusion-RP C18 (4.6 mm×250 mm, 4 μm) columon was ud, the mobile pha was methanol-water (65步入式衣帽间35), the detection wave length was 343 nm and flow velocity was 1.0 mL/min. The determination conditions of dissolution were lected by the index of cumulative dissolution rate of piperin
佛手瓜种植
e, accumulation dissolution curves were calculated, drawn. Results The determination conditions of dissolution included paddle method with the rotating speed of 100 r/min and water as dissolution medium. 80% piperine in majun was dissolved in 60 min, and 100% was dissolved in 120 min. 60% piperine in powders was dissolved in 60 min, and 90% was dissolved in 120 min. Conclusion The piperine in powders dissolves faster than in Majun.
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标签:溶出度   测定   溶出   条件   散剂
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