ATP-Dependent Chromatin-Remodeling Complexes in DNA Double-Strand Break Repair: Remodeling,
数字红包代表的意思大全Pairing and (Re)pairing
期刊名称： Cell cycle (Georgetown, Tex.)
作者： Huang, Jian,Liang, Bing,Qiu, Jiajing,Laurent, Brehon C.
年份： 2005年
冬日将至
期号： 第12期
蒜头发芽关键词： Animals;Chromatin;Multiprotein Complexes;Adenosine睡前长篇故事
Triphosphate;Chromosome Pairing;Chromatin Asmbly and
Disasmbly;Adenosine Triphosphatas;DNA Damage;DNA Repair
摘要：The genomic integrity of a eukaryotic cell is challenged by over 10,000 chromosomal lesions perday. Therefore the cell has evolved efficient mechanisms
写小白兔的作文
家庭炒菜to recognize, signal, and repair DNAbreaks. Defects in any of the steps can lead
to chromosomal aberrations and cancers. As thelesions must be repaired in the context of chromatin, both chromatin-modifying and nucleosomeremodelingenzymes have been implicated in DNA damage repair. We reported recently that theRSC and Swi/Snf ATP-dependent chromatin-remodeling complexes are involved in DSB repairspecifically by homologous recombination. Here we discuss how such enzymes might be recruitedto DNA breaks, why so many remodelers are recruited to sites of DSBs, and a possible functionalconnection between RSCs roles in sister chromatid cohesion and DSB repair.
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gb18030>蓝白小镇
