Role of TLR4 in the induction of inflammatory changes in adipocytes and macrophages 期刊名称： Adipocyte
作者： K. McKernan,Mita Varghe,R. Patel,K. Singer满而不溢
手机怎么发邮件年份： 2020年
怎样瘦腰
电脑桌面怎么截图期号： 第1期物业安全管理
牙疼吃什么食物好
幼儿保育员关键词： Toll-like receptors;inflammation;adipo tissue
macrophages;adipogenesis;ear menchymal stem cells;bone marrow derived dendritic cells;lipopolysaccharide;saturated fatty acids;cytokines
摘要：In obesity, high levels of saturated fatty acids (SFAs) contribute to adipo tissue inflammation and dysfunction. Obesity-induced macrophage infiltration leads to insulin resistance, but the adipocyte itlf may play a role in generating the inflammatory milieu. Given our recent findings of the role of TLR4 in myeloid biasing in obesity, we next investigated the role of TLR4 in adipocyte generated inflam
matory respons to SFAs and lipopolysaccharides. We ud WT and ear menchymal stem cell derived adipocytes (EMSC Ad) and bone marrow dendritic cells (BMDCs) to evaluate cell specific respons. Our work demonstrates a role for TLR4 in adipocyte- immune cell crosstalk and that SFA derived metabolites from adipocytes may induce proinflammatory stimulation of immune cells in a TLR4 independent manner.煮泡面
内容由中国教育图书进出口有限公司引进
