Lower brain-derived neurotrophic factor levels associated with worning fatigue in prostate cancer patients during repeated stress from
radiation therapy
弥尔顿期刊名称： World Journal of Biological Psychiatry
苏州古镇排名作者： L.N. Saligan,N. Lukkahatai,G. Holder,B. Walitt,R. Machado-Vieira
年份： 2015年建设规模
尊敬的反义词期号： 第8期检讨书应该怎么写
关键词： fatigue;depression;brain-derived neurotrophic factor;radiation;prostate neoplasm
摘要：Objectives. Fatigue during cancer treatment is associated with depression. Neurotrophic factors play a major role in depression and stress and might provide insight into mechanisms of fatigue. This study investigated the association between plasma concentrations of three neurotrophic factors (BDNF,
brain-derived neurotrophic factor; GDNF, glial-derived neurotrophic factor; and SNAPIN, soluble N-ethylmaleimide nsitive fusion attachment receptor-associated protein) and initial fatigue intensification during external beam radiation therapy (EBRT) in euthymic non-metastatic prostate cancer men. Methods. Fatigue, as measured by the 13-item Functional Asssment of Cancer Therapy-Fatigue (FACT-F), and plasma neurotrophic factors were collected at baline (prior to EBRT) and mid-EBRT. Subjects were categorized into fatigue and
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