Sodium Hydride 60% Dispersion in Oil
关于植物的资料Description
Sodium hydride is ud as a deprotonating agent in condensation and alkylation reactions, and as a polymerization catalyst.
Sodium hydride is insoluble in most solvents, including ethers, hydrocarbons, amines and ammonia. It is offered by Rohm and Haas as a 60 ± 3% NaH microcrystalline dispersion in mineral oil. The particle size range is typically 5-50µ.
Typical Physical Properties
The properties are typical but do not constitute specifications.
Formula NaH
Molecular Weight 24.00
Form Microcrystalline dispersion of gray powder in mineral oil.
风景的成语Specification NaH: 60% ± 3%
Diluent Mineral oil: 40% ± 3%
The mineral oil is freely miscible with a wide range of hydrocarbons not
基辅英语
affecting the activity of sodium hydride. Examples include hexane, heptane,
diethyl ether, dibutyl ether and toluene.
表达思念的诗Viscosity 75-85 sus @ 100°F
Flash point 340°F
Specific Gravity 0.84-0.86 (25°C)
Pure sodium hydride dissociates on heating, starting at about 225°C. The relationship of equilibrium pressure to temperature is expresd by the equation:
Log10P = -6100 / T + 11.66(1)
where P = pressure in mm Hg
T = temperature in K
(1) Herold, Compt. rend 228, 686 (1949)
As for the dispersion in mineral oil, NaH starts deprotonating oil at temperatures above 300°C.
Water Reactivity
CAUTION: Upon reaction of sodium hydride dispersion with water, H2 and NaOH are formed. This hydrolysis reaction is vigorous and exothermic.
Application
Condensations
Sodium hydride in oil rembles sodium and sodium alcoholates in its ability to function as a deprotonating agent in the Acetoacetic ester, Clain, Stobbe, Dieckmann, and related condensations. It posss marked advantages over other condensing agents in that:
1.It is a stronger ba, which results in a more straightforward deprotonation
2.No excess is needed
3.Alcoholates add an alcohol to the reaction mixture, which may need to be distilled out to drive the
condensation equilibrium – NaH results in only H2 gas as a reaction by-product
4.The evolving H2 gives a measure of the extent of the reaction
5.Side reactions such as reductions are eliminated
Alkylations
Alkylations of aromatic and heterocyclic amines such as 2-aminopyridine and phenothiazine are readily accomplished in high yield using toluene-dimethylformamide mixtures. The dimethylformamide concentration is a variable ud to control the rate of reaction.
Polymerization
Several literature examples indicate the ufulness of sodium hydride in polymerization to form capr
olactams and glycol ethers.
Product Stewardship
Rohm and Haas’ 60% NaH dispersion is not pyrophoric, but it has some inherent handling risk due to its
‘Dangerous When Wet’ classification. Therefore, Rohm and Haas lls this product as part of a comprehensive Product & Services package, which includes :
z The highest NaH product quality
z A formulation in mineral oil which is stable under various transport conditions
z The availability of a choice of solvent soluble bags and package sizes
z Safety audits and training
z Technical advice with regards to both the safe handling and the cost-efficient synthetic u
Availability/Packaging/Shipping
Sodium hydride dispersion is available in 15 kg and 90 kg drums containing individual 5 kg units, which are packaged in the solvent soluble bag of choice. Two 5 kg units are then packed together in a polyethylene bag, which is placed in friction top cans or metal pails.
孝顺竹
Special packaging is available to meet specific process needs.
Shipment is governed by US DOT regulations 173:153 and 173:154.
Toxicity and First Aid
Sodium hydride dispersion is considered to be toxic if ingested due to the caustic formed by reactions with water, and to possible gas embolism resulting from reaction with stomach acids. In ca of ingestion, do not induce vomiting. Contact a physician immediately and transfer the person to a medical facility.
软笔书法字帖
Sodium hydride dispersion is considered corrosive to skin or eyes, also becau of the potential for caustic byproducts from reactions with moisture. In ca of eye contact, flush with large amounts of water, under eyelids for at least 15 minutes, and ek medical attention immediately thereafter. In ca of skin contact, brush off immediately and flush the affected area with water. Seek medical attention if irritation persists.
Sodium hydride dispersion is non-dusting. However, reacting material can emit a fine caustic mist. In ca of inhalation, rin mouth with water and move to fresh air. Seek medical attention immediately.
All precautions should be taken against ingestion, inhalation and eye or skin contact with sodium hydride dispersion or reaction products. Refer to the Material Safety Data Sheet for additional information or contact Rohm and Haas Company.
Handling and Storage
Sodium hydride disperd in oil is not a pyrophoric material, but material adhering to covers and side walls of containers may ignite when expod to humid air. Therefore, protective rubber gloves, clothing and face shields should be worn when handling sodium hydride. The dispersion should be handled in the same manner as other hygroscopic materials. Store in a clean dry area and keep containers tightly clod. Transfer of hydride to other containers should be done only after container has been baked dry, cooled and flushed with nitrogen. Sodium hydride reactions should always be carried out in adequately vented vesls.
Rohm and Haas’ dispersion of 60 ± 3% NaH is a safe stable material to handle. Still, depending on the transport and storage conditions, some mineral oil may drain away from the hydride particle on st
anding resulting in a dispersion on top of the container which must be handled with caution as indicated.小兵张嘎电影观后感
Fire Precautions
养生酒配方大全Sodium hydride dispersion is classified ‘Dangerous When Wet’. Upon reaction with water, hydrogen gas and sodium hydroxide (H2 + NaOH) are formed. This hydrolysis reaction is vigorous and exothermic. When not vented appropriately, there is a risk of H2 ignition.
CAUTION: POWDERED LIMESTONE FOR SMOTHERING FIRES SHOULD BE AVAILABLE. DO NOT USE WATER, SODA ACID, CHEMICAL OR CARBON DIOXIDE EXTINGUISHER. THE ONLY RECOMMENDED FIRE EXTINGUISHER IS THE NITROGEN PROPELLED DRY POWDER TYPE. REFER TO THE MATERIAL SAFETY DATA SHEET FOR MORE DETAILS. Trademark of Rohm and Haas Company or its subsidiaries or affiliates.
To the best of our knowledge the information contained herein is correct. All products may prent unknown health hazards and should be ud with caution. Although certain hazards are described herein, we cannot guarantee that the are the only hazards which exist. Final determination of suitability of the product is the sole responsibility of the ur. Urs of the product should satisfy the
mlves that the conditions and methods of u assure that the product is ud safely.
No reprentations or warranties, either expresd or implied, of merchantability, fitness for a particular purpo or any other nature are made hereunder with respect to the information contained herein or the product to which the information refers. Nothing herein is intended as a recommendation to u our products so as to infringe any patent. We assume no liability for customer’s violation of patent or other rights. The customer should make his own patent investigation relative to his propod u.
©Rohm and Haas, 2007 All rights rerved. December 2004
