Risk of Alzheimer's dia is associated with a very low-density lipoprotein receptor genotype in
northern Ireland (p 140-144)
期刊名称： American Journal of Medical Genetics Part B Neuropsychiatric
Genetics
年份： 2010年
期号： 第2期
关键词： Alzheimer's dia ; VLDL-R ; APOE
摘要：The -4 allele of apolipoprotein E (APOE) is associated with incread risk
of Alzheimer's dia (AD), but the pathogenic mechanism is unknown. The 5-repeat allele of a CGG repeat polymorphism in the 5 untranslated region of the
very low-density lipoprotein receptor (VLDL-R) gene, a receptor for apoE, has been found to be associated with incread risk of AD in a Japane population. Other groups have been unable to replicate this in American Caucasian populations. A
ca-control study utilizing a clinically well-defined group of late-ont AD patients (n = 108) and age- and x-matched control subjects (n = 108) from Northern Ireland was performed to test this association in a relatively homogeneous population. The 9,9 genotype of the VLDL-R was found to be significantly incread
in patients compared to controls (P = 0.003; Pcorr = 0...
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