Graft﹙ersus﹉ost dia in recipients of grafts from natural killer T cellヾeficient (Jα281–/–) donors
期刊名称： Immunology
作者： Cynthia A. Ellison,Masaru Taniguchi,Jacqie M. M. Fischer,Kent T.
Hayglass,John G. Gartner
作者机构： RIKEN Rearch Center for Allergy and Immunology, Tsurumi,
Yokohama, Japan,Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada,Department of Immunology, University of Manitoba,
Winnipeg, Manitoba, Canada
年份： 2006年
期号： 第3期
关键词： graft-versus-host dia (GVHD); CD1-restricted natural killer T cells (NKT cells); helper T cells: Th cells, Th0, Th1, Th2, Th3; animal models/studies: mice
摘要：Vα14i natural killer T cells (NKT cells) are a CD1-restricted subt of NKT cells that express an invariable Vα14+ Jα281+αβ T-cell receptor. To determine whether the abnce of Vα14i NKT cells from the graft affects the development of acute GVHD, we induced GVH reactions using Jα281–/– mice as donors in the
C57BL/6→(C57BL/6 × DBA/2)F1-hybrid strain combination. Recipients of grafts from Jα281–/– donors were not protected from either the morbidity or the vere wasting syndrome associated with the development of acute GVHD, but the concentrations of some T helper 1 (Th1) and Th2 cytokines were different from tho en in recipients of grafts from wild-type donors. Interferon-γ was en earlier (day 4) in recipients of grafts from Jα281–/–
内容由中国教育图书进出口有限公司引进
