Graft﹙ersus﹉ost dia in recipients of graft

更新时间:2023-05-10 16:44:13 阅读: 评论:0

Graft﹙ersus﹉ost dia in recipients of grafts from natural killer T cellヾeficient (Jα281–/–) donors
期刊名称: Immunology
作者: Cynthia A. Ellison,Masaru Taniguchi,Jacqie M. M. Fischer,Kent T.
Hayglass,John G. Gartner
作者机构: RIKEN Rearch Center for Allergy and Immunology, Tsurumi,
Yokohama, Japan,Department of Pathology, University of Manitoba, Winnipeg, Manitoba, Canada,Department of Immunology, University of Manitoba,
Winnipeg, Manitoba, Canada
年份: 2006年
期号: 第3期
关键词: graft-versus-host dia (GVHD); CD1-restricted natural killer T cells (NKT cells); helper T cells: Th cells, Th0, Th1, Th2, Th3; animal models/studies: mice
摘要:Vα14i natural killer T cells (NKT cells) are a CD1-restricted subt of NKT cells that express an invariable Vα14+ Jα281+αβ T-cell receptor. To determine whether the abnce of Vα14i NKT cells from the graft affects the development of acute GVHD, we induced GVH reactions using Jα281–/– mice as donors in the
C57BL/6→(C57BL/6 × DBA/2)F1-hybrid strain combination. Recipients of grafts from Jα281–/– donors were not protected from either the morbidity or the vere wasting syndrome associated with the development of acute GVHD, but the concentrations of some T helper 1 (Th1) and Th2 cytokines were different from tho en in recipients of grafts from wild-type donors. Interferon-γ was en earlier (day 4) in recipients of grafts from Jα281–/–
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