Adjuvanted oral vaccines should not induce allergic respons to dietary antigens
期刊名称： FEMS Microbiology Letters
作者： Duncan E.S. Stewart-Tull,Anne C. Jones
年份： 1993年
期号： 第1-3期
关键词： Oral vaccine;Adjuvant;Food allergy;Freund's adjuvant;Vaccine
摘要：Oral vaccines may contain adjuvants which might elicit allergies against dietary proteins. Four antigens were ud to measure such an effect--ovalbumin, soya bean protein, lactalbumin and gluten. Neither guinea pigs nor mice showed IgE respons after oral administration of adjuvanted vaccines containing lactalbumin and gluten. No IgE respons were detected in mice with any of the antigens
after oral immunization, but, in the guinea pig, nine out of 18 animals reacted to either ovalbumin or soya bean protein and none reacted to lactalbumin and gluten.
It is concluded that the risk of allergy induction against normal dietary proteins is low but such tests should be applied to potential adjuvanted oral vaccines to measure any possible contraindication, especially with atopic individuals.
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