Characterization and Quantitative Analysis of D法网男单决赛直播
NA Adducts Formed from Lower Chlorinated PCB-
Derived Quinones
期刊名称： Chemical Rearch in Toxicology
作者： Zhao, Shouxun, Narang, Amarji如何做外贸生意
t, Ding, Xinxin, Eadon, George
年份： 2004年
期号： 第4期
关键词： Polychlorinated Biphenyls;Phosphorus Radioisotopes;Quinones;DNA
Adducts;Envi骑单车能减肥吗
ronmental Pollutants;Oxidation-Reduction;Mass
Spectrometry;Chromatography, High Pressure Liquid
摘要：Polychlorinated biphenyls are wide pollutants readily detected in environmental and human spec
imens. DNA adduction occurs through the corresponding quinones. Polychlorinated biphenyls are first metabolized to arene oxides, which can be further oxidized to dihydroxy metabolites by microsomal cytochrome p450s. The catechol and hydroquinone products are further oxidized
by peroxidas to quinones, 血糖高吃什么药
which are electrophilic and capable of reacting with DNA to form adducts. DNA adduction is initiated by Michael addition preferentially to guanosine followed by stabilization through enolization. An虔诚什么意思
other nucleophilic attack forms a five-membered ring, which aromatizes by dehydration to form the final adduct. This report describes the characterization and quant卡通手机壁纸
itative study of DNA adducts formed from lower chlorinated
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