致癌物分类
IARC根据对人类和对实验动物致癌性资料,以及在实验系统和人类其他有关的资料(包括癌前病变、肿瘤病理学、遗传毒性、结构—活性关系,代谢和动力学,理化参数及同类的生物因子)进行综合评价,将环境因子和类别、混合物及暴露环境与人类癌症的关系分为下列五类四组:
第一类:致癌
组1,对人类是致癌物。对人类致癌性证据充分者属于本组。如吸烟和二手烟。
第二类:很可能致癌
组心灵鸡汤经典语录励志2,对人类是很可能或可能致癌物。又分为两组,即组2A和组2B。
组2A,对人类很可能(probably)是致癌物,指对人类致癌性证据有限。对实验动物致癌性证据充分。如生产艺术玻璃、常用电吹风的理发师。
第三类:可能致癌
组2B,对人类是可能(possible)致癌物,指对人类致癌性证据有限,对实验动物致癌性证据并不充分;或指对人类致癌性证据不足,对实验动物致癌性证据充分。
第四类:未知
组3,现有的证据不能对人类致癌性进行分类。
第五类:很可能不致癌
组4,对人类可能是非致癌物。
编辑本段致癌物五类明细表
IARC专家组在2010年1月最新报告对834种环境因子和类别、混合物及暴露环境与人类癌症关系评价结果,
其中组1有100种,组1B有68种,组2B有246种,组3有516种,组4有1种。
IARC对化学物质引起人类癌症危险性评价,是目前公认的权威性资料。在要了解某种化
学物的致癌性时,应首先查阅IARC的资料(网址http:193.51.164.11/monoeval/crthgr01.html)。梦到黑蛇
毒理学网 2010年1月轮扁斫轮12日
Overall Evaluations of Carcinogenicity to Humans
Group 1: Carcinogenic to humans (100)
Agents and groups of agents
4-Aminobiphenyl [92-67-1] (Vol. 1, Suppl. 7; 1987)
Arnic [7440-38-2] and arnic compounds (Vol. 23, Suppl. 7; 1987) (NB:
This evaluation applies to the group of compounds as a whole and not
necessarily to all individual compounds within the group)
Asbestos [1332-21-4] (Vol. 14, Suppl. 7; 1987)
Azathioprine [446-86-6] (Vol. 26, Suppl. 7; 1987)
Benzene [71-43-2] (Vol. 29, Suppl. 7; 1987)
Benzidine [92-87-5] (Vol. 29, Suppl. 7; 1987)
Benzo[a]pyrene [50-32-8] (Vol. 32, Suppl. 7, Vol. 92; in preparation)
(NB: Overall evaluation upgraded from 2B to 1 bad on mechanistic and
other relevant data)
Beryllium [7440-41-7] and beryllium compounds (Vol. 58; 1993)
N,N-Bis(2-chloroethyl)-2-naphthylamine (Chlornaphazine) [494-03-1] (Vol.
4, Suppl. 7; 1987)
Bis(chloromethyl)ether [542-88-1] and chloromethyl methyl ether [107-30-2]
(technical-grade)
(Vol. 4, Suppl. 7; 1987)
1,4-Butanediol dimethanesulfonate (Busulphan; Myleran) [55-98-1] (Vol. 4,
Suppl. 7; 1987)
Cadmium [7440-43-9] and cadmium compounds (Vol. 58; 1993)
Chlorambucil [305-03-3] (Vol. 26, Suppl. 7; 1987)
1-(2-Chloroethyl)-3-(4-methylcyclohexyl)-1-nitrosourea (Methyl-CCNU;
Semustine) [13909-09-6] (Suppl. 7; 1987)
Chromium[VI] (Vol. 49; 1990)
Ciclosporin [79217-60-0] (Vol. 50; 1990)
Cyclophosphamide [50-18-0] [6055-19-2] (Vol. 26, Suppl. 7; 1987)
Diethylstilboestrol [56-53-1] (Vol. 21, Suppl. 7; 1987)
Epstein-Barr virus (Vol. 70; 1997)
Erionite [66733-21-9] (Vol. 42, Suppl. 7; 1987)
Estrogen-progestogen menopausal therapy (combined) (Vol. 72, Vol. 91; in
preparation)
异性推油 Estrogen-progestogen oral contraceptives (combined) (Vol. 72, Vol. 91; in
preparation)
简单的画画教程
(NB: There is also convincing evidence in humans that the agents confer
a protective effect against cancer in the endometrium and ovary)
数学家的故事50字左右 Estrogens, nonsteroidal (Suppl. 7; 1987) (NB: This evaluation applies to
the group of compounds as a whole and not necessarily to all individual
compounds within the group)
Estrogens, steroidal (Suppl. 7; 1987) (NB: This evaluation applies to
有趣的灵魂the group of compounds as a whole and not necessarily to all individual
compounds within the group)
Estrogen therapy, postmenopausal (Vol. 72; 1999)
Ethylene oxide [75-21-8] (Vol. 60; 1994) (NB: Overall evaluation upgraded
from 2A to 1 with supporting evidence from other relevant data)
Etoposide [33419-42-0] in combination with cisplatin and bleomycin (Vol.
76; 2000)
Formaldehyde [50-00-0] (Vol. 88; 2006)
Gallium arnide [1303-00-0] (Vol. 86; 2006)
[Gamma Radiation: e X- and Gamma (g)-Radiation]
Helicobacter pylori (infection with) (Vol. 61; 1994)
Hepatitis B virus (chronic infection with) (Vol. 59; 1994)
Hepatitis C virus (chronic infection with) (Vol. 59; 1994)
Human immunodeficiency virus type 1 (infection with) (Vol. 67; 1996)
Human papillomavirus types 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59
and 66 (Vol. 64, Vol. 90; in preparation) (NB: The HPV types that have
been classified as carcinogenic to humans can differ by an order of
magnitude in risk for cervical cancer)
Human T-cell lymphotropic virus type I (Vol. 67; 1996) 熨斗古镇
Melphalan [148-82-3] (Vol. 9, Suppl. 7; 1987)
8-Methoxypsoralen (Methoxsalen) [298-81-7] plus ultraviolet A radiation
(Vol. 24, Suppl. 7; 1987)