Preparation and characterization of Compritol 888 ATO matrix tablets for the sustained relea of
钱学森夫人蒋英
diclofenac sodium
水浒传林冲
皱越签证官期刊名称： Pharmaceutical Development & Technology
周瑜王者荣耀作者： Roberts, Matthew,Pulcini, Lia,Mostafa, Shabbir,Cuppok-Rosiaux,
Yvonne,Marchaud, Delphine
买车陷阱659年年份： 2013年
期号： 第4期
卤菜制作关键词： Fluid bed;glyceryl behenate;lipophilic matrix;rotary press simulator;wet granulation
摘要：The preparation of lipophilic matrix tablets for the sustained relea of water soluble drugs via direct compression is not always feasible due to poor flow and rapid drug relea. The aim was to evaluate the potential for developing sustained-relea diclofenac sodium tablets, using Compritol 888
ATO as a lipid matrix, by a wet granulation technique. The effects of wet granulation method (planetary mixer and fluid-bed) and liquid binder type (HPMC Metolo 603, 606 or 615) on weight uniformity, tensile strength and relea rates were investigated. The influence of compression force and speed during tablet manufacture under simulated rotary press production conditions were also evaluated. Rapid relea of diclofenac sodium from directly compresd matrices was obrved. A wet granulation technique using different HPMC
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