CHARACTERIZATION AND VALIDATION OF INHIBITORS AND

更新时间:2023-07-28 08:35:41 阅读: 评论:0

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我会一直想你专利名称:CHARACTERIZATION AND VALIDATION OF INHIBITORS AND LIGANDS OF DIPEPTIDYL
AMINOPEPTIDASE IV (DP IV)
发明人:ANSORGE, Siegfried,BANK, Ute,NORDHOFF, Karsten,TÄGER, Michael
申请号:EP2011/054040
申请日:20110317
公开号:WO2011/113895A2客厅风水禁忌
六一儿童节的作文公开日:
20110922
专利内容由知识产权出版社提供巴西铁树
专利附图:
摘要:The invention relates to a method for characterization and validation of
inhibitors or ligands of DPIV, DP8 or DP9 by their interaction with specific binding sites in silico and in vitro. It describes the u of special binding properties at the binding site of the DPIV in the central pore of DPIV, which is distant from the catalytic domain by at least 10 Angström (1 nm) which is esntial for the steric inhibition of this peptida and related enzymes like DP8 and DP9 by DPIV ligands or steric inhibitors for the u of the compounds to suppress DNA synthesis of lymphocytes, dermal cells and other cells. This finding is also important in that this technique can be ud to predict unwanted side effects of DPIV related drugs and exclude effects of DPIV inhibitors developed for the treatment of Diabetes mellitus type II on immune functions and vice versa.
申请人:IMTM GmbH,ANSORGE, Siegfried,BANK, Ute,NORDHOFF, Karsten,TÄGER, Michael
地址:DE,DE,DE,DE,DE
狗有什么品种>七夕又称国籍:DE,DE,DE,DE,DE
代理人:Koepe & Partner
玉叶金花
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