MAb Process Development: Where should China be heading?
Chris Chen, Ph.D.
Senior Vice President and
看风水罗盘Chief Technology Officer, Biologics Service WuXi AppTec Co Ltd
August 2011
Outline
Explosive growth of global MAb industry Cell culture productivity gain
Progress of MAb development in China Gaps of Mab development in China
WuXi AppTec filling the gaps
Closing thoughts
Explosive Growth of MAb Industry
Data courtesy of B Strohl
2011/8/26
Product
Sales
(Billion)
Company Name
Lipitor $13.5 Pfizer Plavix $7.3 Sanofi-Aventis Nexium $7.2 AstraZeneca Seretide/Advair
$7.1 GlaxoSmithKline Enbrel $5.3 Amgen, Wyeth,
Takeda
Zyprexa $5 Eli Lilly Risperdal $4.9 Johnson & Johnson Seroquel
$4.6
AstraZeneca
Singulair $4.5 Merck Aranesp
纯绿色全屏$4.4
祝福的英语Amgen
2007 worldwide sales data - IMS捣鸡
Top 10 Blockbuster Drugs in 2007
Two biologics
Enbrel & Aranesp
奋斗的句子
2011/8/26
Rank Product Company
Technology
WW
给女朋友的暖心情话
sales($m) 1 Avastin Roche
Monoclonal antibody 9,232 2 Humira Abbott + Eisai Monoclonal antibody 9,134 3 Rituxan Roche
Monoclonal antibody 7,815
4 Enbrel Wyeth + Amgen + Takeda
Recombinant product 6,583 5 Lantus Sanofi-Aventis Recombinant product 6,386 6 Herceptin Roche Monoclonal antibody
5,796
7 Crestor AstraZeneca
反担保合同
Small molecule chemistry 5,739
8 Spiriva Boehringer Ingelheim Small molecule chemistry 5,552 9 Remicade
SGP + J&J + Mitsubishi
Tanabe
Monoclonal antibody
5,220
10
Gleevec/Glivec Novartis Small molecule chemistry 5,136
Data courtesy of EP Vantage
Top 10 Blockbusters Predicted for 2014
有趣的玩具Seven biologics including 6 mabs
