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Manuscript Number:
Title: Comparison of ATS Open Pivot Valve and St Jude Regent Valve
using a CFD model bad on fluid-structure interaction
Article Type: Full Length Article (max 3000 words)
Section/Category:
Keywords: Fluid-Structure Interaction, Heart Valve, Bileaflet, Hemodynamics, Platelet Activation
Corresponding Author: Mr. Kris Dumont, PhD
Corresponding Author's Institution:
First Author: Kris Dumont, PhD
Order of Authors: Kris Dumont, PhD; Danny Bluestein, PhD; Jan Vierendeels, PhD; Guido van Nooten, PhD; Pascal Verdonck, PhD
Manuscript Region of Origin:
Abstract:
Comparison of ATS Open Pivot Valve and St Jude Regent Valve
CFD-FSI Comparison of ATS Open Pivot Valve and St Jude Regent Valve
Comparison of ATS Open Pivot Valve and St Jude Regent Valve
using a CFD model bad on fluid-structure interaction
Kris Dumont a, Danny Bluestein b, Jan Vierendeels c,
Guido van Nooten d, Pascal Verdonck a
a Cardiovascular Mechanics and Biofluid Dynamics Rearch Unit, IBiTech, Ghent
University, Belgium
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b Department of Biomedical Engineering, Stony Brook University, USA
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c Department of Flow, Heat an
d Combustion Mechanics, Ghent University , Belgium
d Department of Surgery, University Hospital Ghent, Belgium
Keywords
Fluid-Structure Interaction, Heart Valve, Bileaflet, Hemodynamics, Platelet Activation
关于幸福的文案Word Count (Introduction through Discussion): 2983 words
CORRESPONDING AUTHOR
Dumont Kris
Cardiovascular Mechanics and Biofluid Dynamics Rearch Unit
Institure Biomedical Technology, IBiTech
三生三世玄女
Ghent University
Sint-Pietersnieuwstraat 41, Gent, Belgium
e-mail: kris.
phone: 001 631 444 2799
机械制造装备设计
fax: 001 631 444 6646
Abstract
Numerical simulation using Fluid-Structure Interaction (FSI) models is a state of the art method for investigating blood flow in mechanical heart valves. We compare the hydrodynamic performance for two bileaflet valves bad on the commercially available ATS and St-Jude Medical (SJM) valves.
A three-dimensional model of the ATS and SJM valve, housing in a straight geometry with sudden expansion downstream of the valve, was subjected to an aortic flow pattern (60beats/min, cardiac output 4l/min). A fully implicit coupling procedure is achieved using a parate solver for the fluid problem (FLUENT) and for the structural problem. Valve leaflet excursion and pressure differences w
ere calculated, as well as shear stress on the leaflets and accumulated shear stress on particles relead during both forward and backward flow through the open and clod valve, respectively.
In line with other studies, the ATS valve opened to less than maximal opening angle, in contrast to SJM. Nevertheless, maximal and mean pressure gradients and velocity patters through the valve orifices, were comparable. Platelet stress accumulation during forward flow indicated that no platelets experienced a stress accumulation higher than 35dyne.s/cm2, the threshold for platelet activation (Hellums criterium). During regurgitation flow 0.81% of the platelets in the SJM valve experienced a stress accumulation higher than 35dyne.s/cm2 compared to 0.63% for the ATS valve.
The numerical results confirmed that the different design of the ATS and SJM valve leads to different valve leaflet excursion, but with little impact on transvalvular pressure differences.
诗句情话子望个人资料Introduction
掠燕湖Although tremendous rearch efforts are being done within the domain of tissue engineering to develop patient-specific tissue heart valves, there is still an important role for mechanical prosthetic heart valves, and room for improvement on the existing designs. In particular, anti-coagulation therapy remains a major clinical issue (Bluestein et al., 2000; Bluestein et al., 2002; Yin et al., 2004),
and one is still arching for improved valve designs requiring minimal anticoagulation therapy. In addition to the properties of the ud material, the valve hemodynamics play an important role, and blood flow through the valve should be such that stagnation zones with recirculation of flow and prolonged residence times of blood particles are avoided, as well as turbulence and high shear stress zones, initiating platelet activation or leading to hemolysis.
More and more, computational techniques are being ud for heart valve design. With recent advances in computational fluid dynamics (CFD) and the development of numerical algorithms that account for the interaction between the fluid and the valve leaflets (fluid-structure interaction; FSI), the tools have become available to subject the computer designed valves to ‘virtual bench tests’. We have previously demonstrated that we were able to simulate the motion of the leaflets of a bileaflet heart valve in laminar flow conditions, and to calculate valve performance indices that were in good quantitative agreement with in vivo and in vitro data (Dumont et al., 2005). Nevertheless, numerical FSI models have, according our knowledge, not been ud to compare different types of mechanical bileaflet valves, although this has been routinely done in detail in many in vitro and in vivo studies. Provided the availability of a correct
