专利名称：ANTI-PD-1 ANTIBODY AND STABILIZED PREPARATION THEREOF
发明人：ZHANG, Yanzhen，章燕珍,REN, Jie，任杰,MEI, Fei，梅菲,TANG, Peipei，汤沛霈,CHEN, Kun，陈
坤,TAN, Xiaoding，谭小钉
祝星歌词申请号：CN2021/105458
申请日：20210709
公开号：WO2022/012428A1
公开日：
空客和波音的区别
守望先锋大锤20220120不爱说话怎么办
专利内容由知识产权出版社提供
感觉统合
性格忧郁>家常凉皮
专利附图：
摘要：The prent invention relates to an antibody binding to human PD-1 or a
fragment thereof, and a composition containing the anti-human PD-1 antibody or the fragment thereof, the composition preferably being an injection preparation. The anti-human PD-1 antibody performs screening by using a hybridoma technology to obtain an antibody molecule 317 having high affinity binding to both a human PD-1 extracellular region domain recombinant protein and a cell surface human PD-1 and capable of specifically blocking binding of receptors and ligands of PD-1/PD-L1 and PD-1/PD-L2, and a humanized antibody h317 having unchanged affinity and specificity is further obtained by means of a humanization technology is further obtained. According to structural analysis of an antigen-antibody compound crystal, mutants of h317 light and heavy chain CDR regions are constructed, so that a 317-ries derivative antibody is obtained. On the basis of the anti-human PD-1 antibody h317, an antibody stabilized preparation provided by means of three rounds of component lection and concentration optimization improves the storage stability and temperature adaptability of the antibody, and prolongs the storage life of the antibody preparation especially an injection.
申请人：MABWELL (SHANGHAI) BIOSCIENCE CO., LTD.，迈威(上海)生物科技股份有限公司,JIANGSU MABWELL HEALTH PHARMACEUTICAL R&D CO., LTD.，江苏迈威康新药研发有限公司
地址：Floor 4, Building 3# of ZhangJiang Creative Park No.576 Libing Road, Pudong New District Shanghai 201210，中国上海市浦东新区李冰路576号（张江创想园）3号楼4楼, Shanghai 201210,3rd Floor, National New Drug Innovation Ba No.1 Yaocheng Avenue, China Medical City Taizhou, Jiangsu 225300，中国江苏省泰州市中国医药城药城大道1号国家新药创制基地三楼, Jiangsu 225300
国籍：CN,CN,CN,CN
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