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东北豆角RASA4 inhibits the HIFα signaling pathway to suppress proliferation of cervical cancer cells 期刊名称： Bioengineered
作者： Wensheng Xu,Junying Chen,Erling Chen,Jinbing Huang,Qiaoqiao Huang,Ji Li 年份： 2021年
期号： 第2期
今日节气好听的古风音乐关键词： RASA4;proliferation;HIFα;cervical squamous cell carcinoma
情人节电影>梦见黑蛇摘要：RAS p21 protein activator 4 (RASA4) has been recognized as a Ca 2+ -promoted RasMAPK pathway suppressor that inhibits tumor growth. However, the role of RASA4 in cervical squamous cell carcinoma (CESC) remains unclear. The mRNA levels of RASA4 were analyzed using the GEO and GEPIA databas. KaplanMeier analysis and ROC analys were conducted to determine the prognostic and diagnostic values for patients from the TCGA-CSCE cohort. The CCK8 and colony assays were performed to asss the impact of RASA4 ectopic expression and gene inactivation on tumor cell proliferation. In vivo experiments were performed. Lucifera reporter assays and LW6 (a HIFα inhibitor) were employed to verify the regulatory relationship between RASA4 and the HIFa signal
ing pathway. The GEPIA and GEO databa analysis demonstrated poorly expresd RASA4
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