专利名称：CATHEPSIN-ASSOCIAGED GENETICALLY MODIFIED NONHUMAN MAMMAL
发明人：YAMAMOTO, KENJI,NAKAYAMA, KEIICHI 申请号：EP03723398
申请日：20030526
她的背影吉他谱公开号：EP1532861A4关于秋天作文>315活动
公开日：牌子包包
大学生心理健康论文精美的书签20050928
专利内容由知识产权出版社提供
非洲的气候
摘要：Disclod are a cathepsin E gene and a non-human mammalian animal with the cathepsin E-associated gene altered. The cathepsin E-associated gene and the DNA fragment thereof have each a ba quence or a partial amino acid quence as identified by SEQ ID #1. The cathepsin E-associated gene-altered non-human mammalian animal according to the prent invention, such as a cathepsin E-associated gene-altered mou or the like, has the functions of the cathepsin E-associated gene by performing homologous recombination with a targeting vector having two homologous recombination regions, the first homologous recombination region being compod of a DNA fragment of approximately 1.2 kbp prent on the 5'-upstream side of exon 1 and the cond homologous recombination region being compod of a DNA fragment of approximately 7.0 kbp prent on the 3'-downstream side of exon 4. The cathepsin E-associated gene-altered non-human mammalian animals according to the prent invention can be ud effectively for clarification of allergic dias such as atopic dermatitis and so on as well as their dia conditions, and they are expected to be utilized as an experimental animal model for u with experiments on learning disabilities or memory impairments or acceleration of fighting episodes. Moreover, the cathepsin E-
associated gene-altered non-human mammalian animal of the prent invention is expected to be uful for the elucidation of the physiological functions about stress becau it has a very high nsitiveness against stress.
申请人：KYUSHU TLO COMPANY, LIMITED
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