Therapeutic Targeting of Cain Kina 1δ/ε in an Alzheimer's Dia Mou Model 期刊名称： Journal of Proteome Rearch
黄童>达比拉
作者： Paula Adler,Janice Mayne,Krystal Walker,Zhibin Ning,Daniel Figeys
杜甫字
年份： 2019年一到半夜就口干舌燥
期号： 第9期幽默的说说>红楼梦翻译
关键词： memory;hippocampus;circadian;3xTg-AD;mass
山秋spectrometry;proteome;cain kina 1;Alzheimer’s dia
摘要：Sleep disturbancesand memory impairment are common symptoms ofAlzheimer's dia (AD). Given that the circadian clock regulatessleep, hippocampal function, and neurodegeneration, it reprentsa therapeutic target against AD. Cain kina 1δ/ε (CK1δ/ε)are clock regulators and overexpresd in AD brains, making them viabletargets to improve sleep and cognition. In this study, we evaluatedthe therapeutic potential of a small molecule CK1δ/ε inhibitor(PF-670462) in a triple trans
genic mou model of AD (3xTg-AD). Massspectrometry-bad proteomic analys revealed that PF-670462 administrationin 3xTg-AD mice reverd hippocampal proteomic alterations in veralAD-related and clock-regulated pathways, including synaptic plasticityand amyloid precursor protein processing. Furthermore, PF-670462 administrationrescued
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