心累的句子说说心情Formulation Optimization and Stability Study of Transdermal Therapeutic System of Nicorandil 期刊名称： Pharmaceutical Development and Technology
生态园林城市作者： Dnyanesh N. Tipre,Pradeep R. Vavia
爱的歌
长高体操年份： 2002年
不敢高攀
关键词： Nicorandil;N-Methyl-2-pyrrolidone;Pressure nsitive
蔓越莓曲奇adhesive;Transdermal
摘要：The aim of this rearch investigation was to fabricate acrylate-bad stable transdermal therapeutic system (TTS) of nicorandil, which could deliver drug through transdermal route. Monolithic TTS was fabricated in pressure nsitive adhesives (PSAs)--(a) terpolymer (PSA1) of 2-ethylhexyl acrylate, methyl methacrylate, and acrylic acid, (b) copolymer (PSA2) of 2-ethylhexyl acrylate, methyl methacrylate, acrylic acid, and vinyl acetate, and (c) Eudragit E100 pressure nsitive adhesive (PSA3). To enhance the flux of nicorandil, skin permeation enhancer N-methyl-2-pyrrolidone (NMP) wa
跨行转账一般多长时间到账s investigated at different concentrations (0.05-5%) in PSAs. Fabricated TTS was evaluated for in-vitro relea and skin permeation through guinea pig skin. Maximum flux of nicorandil was obrved from Eudragit
E100 bad TTS and kept for stability
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