10 PHILADELPHIA CHROMOSOME MOSAICISM DUE TO ADDITIONAL CYTOGENETIC ABNORMALITIES IN CHRONIC MYELOID LEUKEMIA MIGHT ADVERSELY AFFECT PROGNOSIS AND RESPONSE TO
IMATINIB.
期刊名称: Journal of Investigative Medicine感动老公能哭的一段话
作者: Landstrom, A.,Ketterling, R.,Knudson, R.,Dewald, G.,Tefferi, A.
年份: 2007年
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期号: 第2期三个和尚挑水的故事
摘要:BackgroundChronic myeloid leukemia (CML) is invariably associated with the reciprocal translocation of BCR and ABL to form the Philadelphia chromosome (Ph), t(9;22)(q34;q11). At diagnosis, a small proportion of patients display additional cytogenetic abnormalities and/or a variable proportion of cytogenetically normal metaphas that coexist with Ph-positive metaphas. The objecti
ve of the current study was to examine the prognostic relevance and therapy implications of this消声匿迹
scenario.MethodsThe study population consisted of 65 (47.7% female) concutive, newly diagnod, untreated CML patients en at the Mayo Clinic with a median age of 59 years; 44.5% were initially treated with interferon (IFN)-α, resulting in
遗产税草案complete cytogenetic remission in 10.7%, for a median length of 5.83 years,
whereas partial cytogenetic
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