补肾壮阳Correcting for ascertainment bias of relative-risk estimates obtained using affected-sib-pair linkage鸡皮疙瘩小说
data.教师节手抄报简单
期刊名称： Genetic Epidemiology煎蛋
疲惫的句子作者： Heather J. Cordell,Jane M. Olson
雨滴的拼音年份： 2015年
期号： 第4期
关键词： identity‐by‐descent;model‐free;linkage analysis
心理学自学入门摘要：Locus-specific sibling relative risk is often estimated using affected-sib-pair lod score analysis of affected sibships and may be ud to decide whether to continue or discontinue the arch for additional susceptibility genes. We showed that relative-risk estimates obtained using affected-sib-pair data are asymptotically unbiad when each pair is given a weight inverly proportional to the sibship ascertainment probability. Here we show by simulation that the extent of the bias
of relative risks estimated using the incorrect ascertainment weights is small for dominant models, but large for single-locus recessive models and some two-locus heterogeneity models. Since in practice the ascertainment scheme is often unknown, we investigate methods for jointly estimating ascertainment and relative risks from affected-sibship data.
内容由中国教育图书进出口有限公司引进
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