Oxime ether derivatives having lipoxygena inhibi

更新时间:2023-06-15 03:44:34 阅读: 评论:0

专利名称:Oxime ether derivatives having lipoxygena inhibitory activity
珠海游玩
发明人:Dee W. Brooks,Andrew O. Stewart,Robert G.
Maki
按验申请号:US07/992388
申请日:19921218
公开号:US05326883A
公开日:
猫咪体内驱虫19940705
专利内容由知识产权出版社提供无边无际类似的成语
水光针的副作用和危害
摘要:The prent invention provides certain substituted oxime ether compounds which inhibit lipoxygena enzyme activity and are uful in the treatment of allergic and inflammatory dia states. The compounds of this invention have the structure
##STR1## where M is hydrogen, a pharmaceutically acceptable cation, or a pharmaceutically acceptable metabolically cleavable group; p and q are independently zero or one, with the provisos that (i) p and q may not both be the same; (ii) when p is one and q is zero, R is lected from the group consisting of hydrogen, straight or branched alkyl of from one to twelve carbon atoms, and cycloalkyl of from three to eight carbon atoms; and (iii) when p is zero and q is one, R is lected from the group consisting of hydrogen, alkyl of from one to twelve carbon atoms, cycloalkyl of from three to eight carbon atoms, and --NR.sub.1 R.sub.2.
L.sub.1 is a direct bond or is lected from the group consisting of alkyl of from one to six carbon atoms, alkylenyl, of from one to six carbon atoms, and alkynyl of from two to six carbon atoms; L.sub.2 is a direct bond or is alkyl of from one to six carbon atoms; Z is lected from the group cons
isting of hydrogen, alkyl of from one to six carbon atoms,
and halosubstituted alkyl of from one to six carbon atoms; and A is optionally substituted carbocyclic or heterocyclic aryl, arylalkyl, or aryloxy.
喝酒骰子玩法
申请人:ABBOTT LABORATORIES
关于秋雨的作文>火锅鸡做法代理人:Jerry F. Jansn
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