专利名称：METHODS OF FORMING 4-CHLORO-2-
FLUORO-3-SUBSTITUTED-PHENYLBORONIC
ACID PINACOL ESTERS AND METHODS OF
USING THE SAME
龙凤岛发明人：OPPENHEIMER, Jossian
申请号：US2012/070967
申请日：20121220
香港的天气
春节问候语公开号：WO2013/101665A1
公开日：
广东一本线20130704
小王子读书笔记
小孩晚上睡觉磨牙专利内容由知识产权出版社提供
摘要：Methods include formation of 4-chloro-2 fluoro-3 substituted-phenylboronic acid pinacol esters. The method compris contacting a 1-chloro-3-fluoro-2-substituted benzene with an alkyl lithium to form a lithiated 1-chloro-3-fluoro-2-substituted benzene. The lithiated 1-chloro-3-fluoro-2-substituted benzene is contacted with an electrophilic boronic acid derivative to form a 4-chloro-2-fluoro-3-substituted-phenylboronate. The 4-chloro-2-fluoro-3-substituted-phenylboronate is reacted with an aqueous ba to form a (4-chloro-2-fluoro-3-substituted phenyl)trihydroxyborate. The (-chloro-2-fluoro-3-substituted phenyl)trihydroxyborate is reacted with an acid to form a 4-chloro-2-fluoro-3-substituted phenylboronic acid. The 4-chloro-2-fluoro-3-substituted phenylboronic acid is reacted with 2,3 dimethyl 2,3 butanediol to form 4-chloro-2-fluoro-3-substituted phenylboronic acid pinacol esters. Methods of using 4-chloro-2-fluoro-3-substituted phenylboronic acid pinacol esters to produce 6 (4-chloro-2-fluoro-3-substituted phenyl) 4 aminopicolinates are also disclod.
申请人：DOW AGROSCIENCES LLC
A53排列组合
地址：46268 US
干旱区研究
国籍：US
代理人：CATAXINOS, Edgar, R.更多信息请下载全文后查看
