A randomized, double-blind, placebo-controlled study of the efficacy and safety of MNK-795, a dual-layer, biphasic, immediate-relea and extended-
relea combination analgesic for acute pain
烧烤腌制配方
期刊名称： Current Medical Rearch & Opinion过去分词做状语
沾沾自喜的反义词作者： Singla, Neil,Barrett, Thomas,Sisk, Lisa,Kostenbader, Kenneth,Young,
什么拼音
Jim,Giuliani, Michael
年份： 2014年
期号： 第3期
关键词： Acute pain; Bunionectomy; Efficacy; Opioid analgesic; Pain intensity; Pain
relief
摘要：To investigate the efficacy and safety of a bilayer combination oxycodone (OC) and acetaminophen (APAP) analgesic with both immediate-relea and金鱼身上长白点
extended-relea (ER) components (OC/APAP ER) in patients with moderate to
vere pain using an established acute pain model. This was a randomized, double-blind, placebo-controlled trial. Adult patients were included in the study if they had
a pain intensity score≥4 on a 0-10 numerical rating scale after bunionectomy
surgery, and were randomized (1:1) to receive four dos (two tablets q12h) of
OC/APAP ER or placebo. NCT01484652. The primary efficacy endpoint was the
summed pain intensity difference over the first 48 hours (SPID48). Secondary
科文中心endpoints included SPIDs and total pain relief (TOTPAR) over the dosing intervals;武松打虎简笔画
time to perceptible, meaningful, and confirmed pain relief;
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