TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathway 期刊名称： Autophagy
作者： Bae, Seong-Yeon,Byun, Sanguine,Bae, Soo Han,Min, Do Sik,Woo, Hyun
Ae,Lee, Kyunglim
年份： 2017年
哈姆雷特摘抄关键词： autophagy;BCL2;BECN1;MTORC1;TP53 target gene;TPT1/TCTP
李承龙摘要：TPT1/TCTP (tumor protein, translationally-controlled 1) is highly expresd in tumor cells, known to participate in various cellular activities including protein synthesis, growth and cell survival. In addition, TPT1 was identified as a酒后驾驶>户外游戏名称
白蝴蝶花direct target of the tumor suppressor TP53/p53 although little is known about the mechanism underlying the anti-survival function of TPT1. Here, we describe a role of TPT1 in the regulation of the MTORC1 pathway through modulating the molecular machinery of macroautophagy/autophagy. TPT1 i工作总结代写
nhibition induced cellular autophagy via the MTORC1 and AMPK pathways, which are inhibited and activated, respectively, during treatment with the MTOR inhibitor rapamycin. We also found that the depletion of TPT1 potentiated rapamycin-induced autophagy by synergizing with MTORC1 inhibition. We further
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