Malaria Vaccine:
Will it be available soon?
Joe Cohen
怎样去斑
华为手机nfcVice President, Vaccines for Emerging Dias & HIV
The Intolerable Burden of Malaria
•600 M at risk
•300-500 M cas/yr •1-3 M deaths/yr
•Most occur in children under 5 years of age
Snow et al., Nature 2005; 434:214-7
•Loss to economies 1980-1995: $74 billion
Sachs et al., Nature 2002; 415:680-5
Tools available today
•Incticide-treated bednets •Indoor residual spraying •Improved ca management •Artemisinin combinations Tools available in the future?
A malaria vaccine
The challenges: Plasmodium, the etiologic agent of Malaria
Protozoan with a large genome : 26-30 megabas; 5-
6000 genes; 14 chromosomes
Allelic and antigenic variation把握商机
Complex, genetically variable, human
immune respon
Multistage life cycle with stage specific
expression of proteins
The challenges:
Parasite life cycle, dia and vaccine
Pre-Eryt hrocytic Axua l Erythro cytic
梦到鬼魂Transm ission Blockin g
Malaria Vaccine Development
strategies are stage specific Pre or exo-erythrocytic stage vaccine
(sporozoites and intra-hepatic parasites): prevents infection and/or reduces incidence and verity of dia
Axual blood stage vaccine (free merozoites and parasitized RBCs): reduces dia incidence and verity
Sexual blood stage / transmission blocking (altruistic) vaccine (gametocytes, gametes and/or zygote
s): prevents man to mosquito transmission
秘制烤鱼Pre-
Erythro
cytic
番茄的英语Axua
l
天伦是什么意思Erythro
cytic Transm
ission
Blockin杭州周边游
g
