a是什么专利名称：COMBINATION THERAPY FOR
NONALCOHOLIC STEATOHEPATITIS (NASH)
AND LIVER FIBROSIS
发明人：LAU, Walter,WANG, Christopher,SHO,
幼儿园吃饭Shonan
申请号：EP17835977.4纵然一夜风吹去
申请日：20171228
公开号：EP3562490A1
汉魂公开日：
20191106
专利内容由知识产权出版社提供
摘要：The innovation is directed to a method for treating a CCR5 and/or CCR2 mediated dia such as nonalcoholic steatohepatitis (NASH) comprising administering an effective amount of a C-C Chemokine receptor 5 (CCR5) antagonist (e.g., maraviroc or vicriviroc or cenicriviroc) and/or an effective amount of a C-C Chemokine receptor 2 (CCR2) antagonist, or a CCR5/CCR2 antagonist together with an effective amount of farnesoid X receptor (FXR) agonist (e.g., obeticholic acid (OCA)). An “effective amount” can be a regular clinical do of either agent alone or a reduced do of the FXR receptor agonist and/or the CCR5/CCR2 antagonist. The combination is effective to treat NASH with (1) enhanced efficacy and (2) substantial reduction of side effects, particularly tho associated with administration of OCA or its analogues, namely less effect on liver enzyme elevation, and less verity and frequency of pruritus (3). The fixed do combination provides for better efficacy and safety profile.
缅甸南部有危险吗
歌曲今夜无眠原唱>年轻的女教师申请人：Modunex Bio Corp.信心的反义词
地址：3rd Floor J&C Building P.O. Box 933 Road Town, Tortola VG 1110 VG
国籍：VG
代理机构：Snodin, Michael D.更多信息请下载全文后查看
