一家十口猜一个字>一流水准打一字Regulation of the IL-12/IL-12R axis: a critical step in T-helper cell differentiation and effector function.
期刊名称： Immunological Reviews成人大专作文
作者： Francesco Sinigaglia,Daniele D'Ambrosio,Poola Panina-Bordignon,Lars
Rogge
作者机构： Roche Milano Ricerche, Milan, Italy.
年份： 2010年扫描件怎么弄
期号： 第1期
重写和重载关键词： Animals;Humans;Antigen-Prenting Cells;Th1 Cells;Dia Models,
Animal;Interferons;Receptors, Interleukin;Interleukin-12;Interleukin-18;Signal
飞车网名Transduction
踌躇不前的意思
摘要：Summary: Interleukin (IL)-12 is required for the development of T-helper (Th)1 cells, which have been shown to be important for protective cell-mediated immune respons against a variety of intracellular pathogens. Recent studies have clarified the sources and the regulation ofIL-12 production leading to Th1 development against microbes. Expression of IL-12R is necessary for maintaining IL-12 responsiveness and controlling Thl lineage commitment. Advances in this area have included a broader understanding of the factors involved in the regulation of the IL-12R2 signaling component. Expression of this receptor subunit in humans is critically influenced by IL-12 and type I interferons. IL-12 signaling results in STAT4 activation and interferon (IFN)- production. Recent evidence suggests that IL-12
also modulates a number
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