宇宙黑洞
Diastereolective Au-Catalyzed Allene
有意思的对联Cycloisomerizations to Highly Substituted
Cyclopentenes
期刊名称： Organic Letters
作者：
前端模板Ryan,D.,Reeves,Alicia,M.,Phelps,William,A.,T.,Raimbach,Jennifer,M.,Schomake
灰色配色年份： 2017年怎么洗衣服
期号： 第13期
解卦详解摘要：Site- and regiocontrolled Au-catalyzed allene carbocyclizations furnish highly substituted cyclopentenes in >1:1 dr. Significant substitution on the substrate is tolerated, with potential to install five contiguous stereocenters after alkene functionalization. Major challenges include identifying a Au/C
u catalyst that controls both the relative rates of allene epimerization/cyclization and the facial lectivity in addition of a metal enolate to the allene. Experiments to achieve stereodivergent cyclizations and transform key cyclopentenes into uful synthetic building blocks are described.
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