专利名称：Indoline derivatives carrying an amide
function, their preparation and
pharmaceutical compositions containing
凉拌西兰花的做法them残花
4大发明美丽的小兴安岭发明人：WAGNON, JEAN,SERRADEIL-LEGAL,
CLAUDINE,TONNERRE,
BERNARD,PLOUZANE, CLAUDE,NISATO,
DINO
申请号：EP92402213.0
申请日：19920803
公开号：EP0526348B1
钢琴弹奏入门
公开日：
吝啬造句
19980218
专利内容由知识产权出版社提供
摘要：The invention relates to compounds of formula (I) in which - R1 reprents a halogen atom, a C1-C4 alkyl, a hydroxyl, a C1-C4 alkoxy, or a benzyloxy, cyano, trifluoromethyl, nitro or amino group, - R2 reprents a C1-C6 alkyl, a C3-C7 cycloalkyl, a C5-C7 cycloalkene, a phenyl which is unsubstituted or substituted one or a number of times, a C1-C4 alkoxy, a halogen, a trifluoromethyl group, an amino group, or R2 reprents a nitrophenyl which is unsubstituted or substituted one or a number of times; - R3 reprents a hydrogen atom; - R4 reprents a carbamoyl group of formula
CONR6R7; - R5 reprents a C1-C4 alkyl; a 1-naphthyl; a 2-naphthyl; a 5-dimethylamino-1-naphthyl; a phenyl which is unsubstituted or substituted one or a number of times, or R5 reprents a nitrophenyl which is unsubstituted or substituted one or a number of times; - R6 reprents a C1-C6 alkyl, or R6 is similar to R7; - R7 reprents a 4-piperidinyl group;
a 3-azetidinyl group, the said groups being unsubstituted or substituted on the nitrogen by a C1-C4 alkyl, by a benzyloxycarbonyl or by a C1-C4 alkoxycarbonyl; a group (CH2)r itlf substituted by a 2-, 3- or 4-pyridyl group, by a hydroxyl group, or by an amino group which is free or substituted by one or two substituents; - or R6 and R7 together constitute, with the nitrogen atom to which they are bonded, a heterocycle chon from: . morpholine, . thiomorpholine, . thiazolidine or 2,2-dimethylthiazolidine, which is unsubstituted or substituted by R8, . piperazine which is unsubstituted or substituted at the 4 position by a group R''8; . a 5-membered mononitrogenated unsaturated ring substituted by R8 or a 3-, 4-, 5-, 6- or 7-membered mononitrogenated saturated ring substituted by R8 and R9; - R8 reprents R'8 or a group (CH2)r itlf substituted by a hydroxyl or by an amino group which is free or substituted by one or two C1-C4 alkyls; -R'8 reprents a group (CH2)q itlf substituted by a carboxyl group, a C1-C4 alkoxycarbonyl group, a benzyloxycarbonyl group, a carbamoyl group which is free or substituted by a hydroxyl or by one or 2 C1-C4 alkyls, or an aminoc
arbothioyl group which is free or substituted by one or 2 C1-C4 alkyls; - R''8 reprents R'8 or a
西安公积金电话(CH2)2NH2 group which is free or substituted by one or two C1-C4 alkyls; - R9 reprents hydrogen, a halogen, a group (CH2)rOR10, a group (CH2)rNR11R12, a group护士长竞聘
(CH2)sCONR11R'11 or an azido group; - R11 reprents hydrogen, a C1-C4 alkyl, a mesyl or a tosyl; - R11, R'11 and R12 each reprent a hydrogen or a C1-C4 alkyl or R11 reprents hydrogen and R12 reprents a benzyloxycarbonyl or a C1-C4 alkoxycarbonyl; - n reprents 0, 1 or 2; - m reprents 0, 1 or 2; - q reprents 0, 1, 2 or 3; - r reprents 0, 1, 2 or 3, with the limitation that r is not 0 when R8 or R9 is in the position alpha to the intracyclic amide nitrogen; - s reprents 0 or 1; and to its optional salts. The compounds are uful in the treatment of illness of the central nervous system, of the cardiovascular system and of the gastric sphere in man and animals.
申请人：SANOFI,SANOFI SA,SANOFI
地址：FR
国籍：FR
代理机构：Gillard, Marie-Loui 更多信息请下载全文后查看
