专利名称：2-(1-ALKOXY-2-NAPHTHALENYL)-PYRROLE DERIVATIVES, THEIR PREPARATION AND
THEIR USE AS DOPAMINE D3 RECEPTOR百发百中类似成语
ANTAGONISTS
shige
发明人：JOHNSON, Christopher, Norbert,STEMP, Geoffrey
申请号：EP1994003220
申请日：19940926
brantb公开号：WO95/010504P1小学二年级数学上册
公开日：难忘同学情
1995042012月5日是什么星座
秋季吃什么菜专利内容由知识产权出版社提供
摘要：Compounds of formula (I), wherein R1 reprents C¿1-4?alkyl; R?2¿ reprents hydrogen, halogen, C¿1-4?alkyl, C1-4alkoxy, C1-4alkoxyC1-4alkyl, C1-4alkylsulphonyl, trifluoromethylsulphonyl; optionally substituted arylsulphonyl, optionally substituted heteroarylsulphonyl, optionally substituted aralkylsulphonyl, optionally substituted heteroaralkylsulphonyl, nitro, cyano, amino, mono- or di-C1-4alkylamino, trifluoromethyl, trifluoromethoxy, hydroxy, hydroxyC1-4alkyl, C1-4alkylthio, C1-4alkanoyl, C1-
4alkoxycarbonyl, aminosulphonyl, C1-4alkylaminosulphonyl or di-C1-
4alkylaminosulphonyl; and Y reprents a group lected from (a), (b), (c) or (d), wherein in group (a): R?3 and R4¿ independently reprent hydrogen, C¿1-6?alkyl, optionally substituted arylC1-6alkyl or optionally substituted hetereoarylC1-6alkyl; R?5¿reprents C¿1-6?alkyl, C3-6alkenyl or C3-6cycloalkylC1-4alkyl; and R?6¿ reprents C¿1-6?alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, o
ptionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; or NR?5R6¿ forms a heterocyclic ring; in
group (b): R7 reprents C¿1-6?alkyl; C3-6alkenyl; C3-6cycloalkylC1-4alkyl, optionally substituted arylC1-4alkyl or optionally substituted heteroarylC1-4alkyl; and q is 1 to 4; in group (c): R?8 and R9¿ independently reprent hydrogen, C¿1-6?alkyl, optionally substituted arylC1-6alkyl or optionally substituted heteroarylC1-6alkyl; R?10¿reprents an optionally substituted aryl or optionally substituted heteroaryl group; and Z reprents -(CH¿2?)r wherein r is 2 to 8 or -(CH2)sCH=CH(CH2)t where s and t independently reprent 1 to 3; and in group (d): each of m and n independently reprents from 1 to 3; and salts thereof, have activity at dopamine receptors and are potentially uful in the treatment of psychos such as schizophrenia, and intermediates of formulae (II), (VII) and (VIII).
申请人：JOHNSON, Christopher, Norbert,STEMP, Geoffrey
地址：GB,GB,GB
竹子的特点
国籍：GB,GB,GB
代理机构：FLORENCE, Julia,THOMPSON, Clive, Beresford
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