梅州万达广场专利名称：COMPOUNDS AND METHOD FOR
人体最大的器官
60年代老歌REDUCING URIC ACID
什么蛋糕最好吃发明人：O'NEIL, JAMES, DENNEN,BAMAT, MICHAEL, K.,VON BORSTEL, REID, W.,SHARMA,
SHALINI,ARUDCHANDRAN,
RAMACHANDRAN
申请号：EP09762990爱情诚可贵
申请日：20090313
公开号：EP2268141A4
公开日：
20110914
专利内容由知识产权出版社提供
党员要求摘要：Uric acid in mammalian subjects is reduced and excretion of uric acid is incread by administering a compound of Formula I or a pharmaceutically acceptable salt thereof. In Formula I m is 0, 1, 2, 3 or 4; n is 0 or 1; t is 0 or 1; q is 0 or 1; and r is 0, 1 or 2. R6 is hydrogen, O or hydroxyl. R7 is hydrogen or alkyl having from 1 to 3 carbon atoms. One of R8 and R9 is alkyl having from 1 to 3 carbon atoms, and the other is hydrogen or alkyl having from 1 to 3 carbon atoms. R10 is hydrogen, halo, alkyl having from 1 to 3 carbon atoms or alkoxy having from 1 to 3 carbon atoms. X is C(O) and r is 0 and t is 0; or X is
NH(R11) wherein R11 is hydrogen or alkyl having from 1 to 3 carbon atoms. A is phenyl, unsubstituted or substituted by 1 or 2 groups lected from halo, hydroxy, methyl, ethyl, perfluoromethyl, methoxy, ethoxy, and perfluoromethoxy; or a 5 or 6 membered heteroaromatic ring having 1 or 2 ring heteroatoms lected from N, S and O and the heteroaromatic ring is covalently bound to the remainder of the compound of Formula I by a ring carbon; or cycloalkyl having from 3 t
o 6 ring carbon atoms wherein the北京俚语
cycloalkyl is unsubstituted or one or two ring carbons are independently monosubstituted by methyl or ethyl. The uric acid-lowering effects of the Compounds of Formula I are ud to treat or prevent a variety of conditions including gout, hyperuricemia, elevated levels of uric acid that do not meet the levels customarily justifying a diagnosis of hyperuricemia, renal dysfunction, kidney stones, cardiovascular dia, risk for developing cardiovascular dia, tumor-lysis syndrome, and cognitive impairment.
申请人：WELLSTAT THERAPEUTICS CORPORATION
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