大白纸专利名称：NLRC5 AS A BIOMARKER FOR CANCER PATIENTS AND A TARGET FOR CANCER
THERAPY
发明人：KOICHI KOBAYASHI
申请号：US15585761
送穷日面试常问问题申请日：20170503
公开号：US20170321285A1
公开日：
党建指导员
20171109
专利内容由知识产权出版社提供
摘要：The invention pertains to biomarkers for identifying a cancer that is likely or not likely to evade the immune system of a subject, thus, is likely or not likely to show better prognosis (prognostic biomarker) and/or better respons to cancer therapies (predictive biomarker). The invention provides a method of identifying a subject as having a cancer that is likely to evade the immune system of the subject bad on one or more of the following biomarkers in the cancer cells of the subject: a) reduced amount of NLRC5 mRNA or protein; b) reduced activity of NLRC5 protein; c) a mutation that reduces the activity of NLRC5 protein; d) incread methylation of nlrc5 or a portion thereof; and e) reduced copy number of nlrc5. The variables are uful to predict both patient survival (prognostic biomarker) and patient respons to immunotherapies (predictive biomarker). Furthermore, this invention provides a method of identifying a subject as having a cancer that is likely to evade the immune system of the subject with greater prediction power by utilizing multiple variables, in addition to above a)-e) variables, including neoantigen load, mutation number, or expression of genes involved in immune respons, including but not limited to CTLA4, PD1, PD-L1 and PD-L2. The invention also
pertains to a method of treating a cancer likely to evade the immune system of the subject by administering an immunotherapy and a therapy designed to activate the MHC class I antigen prentation pathway by activating the expression and/or activity of NLRC5 protein.方差英文
洋洋得意的意思申请人：THE TEXAS A&M UNIVERSITY SYSTEM
地址：COLLEGE STATION TX US
机械工程及自动化国籍：US
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