专利名称：BI-SPECIFIC ANTIBODY
发明人：HINO FUMITSUGU,KATAYAMA MASAHIKO,KATOU IKUNOSHIN 申请号：JP30614589
肉松卷的做法>湖光秋月两相和潭面无风镜未磨
申请日：19891124
我爱你的句子浪漫公开号：JPH03164192A
公开日：
煎面包>吴尊是哪里人19910716
专利内容由知识产权出版社提供
摘要：NEW MATERIAL:A bi-specific antibody having different antigenic specificities, i.e., activated platelet antigen specificity and antithrombogenic substance specificity, on one antibody molecule. USE:An antithrombogenic agent and a remedy for thrombosis. PREPARATION:The objective bi-specific antibody can be by using an activated platelet specific antibody (e.g. anti-GMP-140 monoclonal antibody) and an antithrombogenic substance specific antibody (e.g. anti-tissue plasminogen activator antibody) as raw materials, digesting the materials with a protea such as pepsin to form F(ab')2 fragments, reducing a disulfide bond bonding H chains of the F(ab')2 fragments to split the F(ab')2 into two half molecules Fab', mixing the Fab' originated from each antibody, oxidizing again under a bonding condition to produce a bi-specific antibody and purifying the antibody with an affinity column containing each antigen in immobilized state.
乌曼申请人：TAKARA SHUZO CO LTD
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