徐佳琪
Novel anti-Sialyl-Tn monoclonal antibodies and antibody-drug conjugates demonstrate tumor specificity and anti-tumor activity 期刊名称： Mabs
作者： Prendergast, Jillian M.,Galvao da Silva, Ana Paula,Eavarone, David
彩虹电热毯怎么样A.,Ghaderi, Darius,Zhang, Mai,Brady, Dane,Wicks, Joan,DeSander, Julie,Behrens,
Jeff,Rueda, Bo R.
年份： 2017年
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关键词： Antibody Drug Conjugate (ADC);breast cancer;CD175s;colon
181年cancer;ovarian cancer;sialyl-Tn;STn;Tumor-Associated Carbohydrate Antigen (TACA)
鞭长莫及摘要：Targeted therapeutics that can differentiate between normal and malignant tumor cells reprent the ideal standard for the development of a successful anti-cancer strategy. The Sialyl-Thomn-nouveau antigen (STn or Sialyl-Tn, also known as CD175s) is rarely en in normal adult tissues, but it
暑假里的一件事is abundantly expresd in many types of human epithelial cancers. We have identified novel antibodies that specifically target with high affinity the STn glycan independent of its carrier protein, affording the potential to recognize a wider array of cancer-specific sialylated proteins. A panel of murine monoclonal anti-STn therapeutic antibodies were generated and their binding specificity and efficacy were characterized in vitro and in in vivo murine cancer models. A subt of the antibodies were conjugated to monomethyl auristatin E (MMAE)...蓝色配黑色好看吗
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