23价肺炎球菌多糖疫苗的规模化生产及质量控制
石帆>微信怎么下载安装23价肺炎球菌多糖疫苗的规模化生产及质量控制
宋绍忠;石晓丽;廖磊;蒋宁;张云;张建华;黎云东;黄剑;徐萌萌;张锐
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国庆英语作文【期刊名称】《中国新药杂志》
公交车道限行时间【年(卷),期】2012(021)010
【摘要】Objective:To improve the productivity and the quality of pneumococcal polysaccharide vaccine for expanding the scale of pneumococcal fermentation, increasing the yield of polysaccharides and reducing the endotoxin content of vaccine; to prepare and calibrate the pneumococcal polysaccharide reference products for enterpris and the rum for qualitatively and quantitatively detecting the 23-valent pneumococcal polysaccharide vaccine. Methods; Pneumococcal amplification fermentation was expanded, and the culture parameters, the feeding mode, feeding time of sugar and alkali in the cultivation were adjusted. The yield of purified polysaccharide was incread by adding the
speed control and the temperature control, adjusting the ethanol concentration in the subparagraph ethanol precipitation process, and controlling the various technical parameters in the phenol extraction process. The endotoxin content in pneumococcal polysaccharide vaccine was reduced by controlling the main raw materials ud in the production process and standardizing the behavior of operators. Rabbits and rats were immunized by polysaccharide to obtain the standard rum. Results; Pneumococcal
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