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横幅标语大全suspension. During such episodes, patients may require therapy with oral corticosteroids.
5.3 Hypernsitivity Reactions Including Anaphylaxis
Hypernsitivity reactions including anaphylaxis, rash, contact dermatitis, urticaria, angioedema, and bronchospasm have been reported with u of budesonide inhalation suspension. Discontinue budesonide inhalation suspension if such reactions occur [e Contraindications (4)].
5.4 Immunosuppression
Patients who are on drugs that suppress the immune system are more susceptible to infection than healthy individuals. Chicken pox and measles, for example, can have a more rious or even fatal cour in susceptible children or adults using corticosteroids. In children or adults who have not had the dias, or been properly immunized, particular care should be taken to avoid exposure. How the do, route, and duration of corticosteroid administration affect the risk of developing a disminated infection is not known. The contribution of the underlying dia and/or prior corticosteroid treatment to the risk is also not known. If expod to chicken pox, therapy with varicella zoster immune globulin (VZIG) or pooled intravenous immunoglobulin (IVIG), as appropriate, may be indicated. If expod to measles, prophylaxis with pooled intramuscular immuno
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globulin (IG) may be indicated. (See the respective package inrts for complete VZIG and IG prescribing information.) If chicken pox develops, treatment with antiviral agents may be considered.
The clinical cour of chicken pox or measles infection in patients on inhaled corticosteroids has not been studied. However, a clinical study has examined the immune responsiveness of asthma patients 12 months to 8 years of age who were treated with budesonide inhalation suspension. An open-label non-randomized clinical study examined the immune responsiveness of varicella vaccine in 243 asthma patients 12 months to 8 years of age who were treated with budesonide inhalation suspension 0.25 mg to 1 mg daily (n=151) or noncorticosteroid asthma therapy (n=92) (ie, beta-agonists, leukotriene receptor创业找哪些投资
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antagonists, cromones). The percentage of patients developing a roprotective antibody titer of ≥5.0 (gpELISA value) in respon to the vaccination was similar in patients treated with budesonide inhalation suspension (85%) compared to patients treated with non-corticosteroid asthma therapy (90%). No patient treated with budesonide inhalation suspension developed chicken pox as a result of vaccination.
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Inhaled corticosteroids should be ud with caution, if at all, in patients with active or quiescent tuberculosis infection of the respiratory tract, untreated systemic fungal, bacterial, viral, or parasitic infections; or ocular herpes simplex.
5.5 Transferring Patients from Systemic Corticosteroid Therapy
Particular care is needed for patients who are transferred from systemically active corticosteroids to inhaled corticosteroids becau deaths due to adrenal insufficiency have occurred in asthmatic patients during and after transfer from systemic corticosteroids to less systemically available inhaled corticosteroids. After withdrawal from systemic corticosteroids, a number of months are required for recovery of hypothalamic-pituitary-adrenal (HPA)-axis function.
Patients who have been previously maintained on 20 mg or more per day of prednisone (or its equivalent) may be most susceptible, particularly when their systemic corticosteroids have been almost completely withdrawn.手洗衣服
During this period of HPA-axis suppression, patients may exhibit signs and symptoms of adrenal insufficiency when expod to trauma, surgery, infection (particularly gastroenteritis) or other conditions associated with vere electrolyte loss. Although budesonide inhalation suspension may
生活的激情provide control of asthma symptoms during the episodes, in recommended dos it supplies less than normal physiological amounts of glucocorticosteroid systemically and does NOT provide the mineralocorticoid activity that is necessary for coping with the emergencies.
During periods of stress or a vere asthma attack, patients who have been withdrawn from systemic
