The u of ATG abrogates the antileukemic effect of cytomegalovirus reactivation in patients with acute myeloid leukemia receiving grafts from unrelated
donors
期刊名称： American Journal of Hematology
作者： Busca, Alessandro,Pasra, Roberto,Pini, Massimo,Zallio,
孙国琴
蔬菜汁Francesco,Dellacasa, Chiara,Audisio, Ernesta,Giaccone, Luisa,Maffini, Enrico,Costa,背叛的英文
Cristina,Cavallo, Rossana,Bruno, Benedetto
发言的英文
年份： 2015年
如何设置壁纸期号： 第6期
关键词： Cytomegalovirus;stem cell transplantation;leukemia;in vivo T-cell
depletion
鼻子痒怎么办
摘要：Several studies provided evidence of a consistent antileukemic effect induced by cytomegalovirus (CMV) replication in acute myeloid leukemia (AML)
patients receiving allogeneic hematopoietic stem cell transplantation (HSCT),
中考历史however the u of antithymocyte globulin (ATG) as graft-versus-host dia
prophylaxis, may potentially abrogate the protective effect of CMV infection. To
address this issue, we retrospectively analyzed the risk of relap in a cohort of 101 patients with AML who received grafts from an unrelated donor after a conditioning regimen including ATG. The cumulative incidence of CMV reactivation, evaluated by RT qPCR, was 59% at 12 months, and 93% of CMV reactivations occurred within the first 100 days post HSCT. The 5-year cumulative incidence of relap in patients with CMV reactivation was 29% compared with 37%
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