专利名称：Lysophosphatidic acid analogs and inhibition of neointima formation
发明人：GABOR TIGYI,DANIEL L. BAKER,CHUNXIANG ZHANG
申请号：AU2004229467
黑芝麻酱温琼申请日：20040409
公开号：AU2004229467B2异常性爱
公开日：
唐朝舞蹈
蔬菜沙拉
20070125
喜爱英文
专利内容由知识产权出版社提供
什么是语音
摘要：The phospholipid growth factor lysophosphatidic acids (LPAs) containing unsaturated fatty acids (18:1, 18:2 and 20:4) and fatty alcohols containing hydrocarbon chains with more than 4 carbons were capable of inducing a rapid formation of neointima, an initial step in the development of atherosclerotic plaque. LPAs with saturated fatty acids did not induce neointima formation. A Peroxisome Proliferator-Activated Receptors gamma (PPARϜ)-specific agonist Rosiglitasone also induced a profound formation of neointima. GW9662, a lective and irreversible antagonist of PPARϜ, abolished LPA- and Rosiglitazone-induced neointima formation, indicating that LPA-induced neointima formation requires the activation of PPARϜ. The data suggest that LPA analogs that bind to but do not activate downstream signaling of PPARϜ or antagonists of PPARϜ that inhibit PPARy signaling would be uful in the prevention and/or treatment of neointima formation and atherosclerosis.
描写思乡的诗句申请人：THE UNIVERSITY OF TENNESSEE RESEARCH FOUNDATION
更多信息请下载全文后查看
