课程代码 356.130.1.01
The teaching outline of Neurobiology 《神经生物学》双语教学大纲
供基础医学专业学生培养用
复旦大学上海医学院
神经生物学系
Chapter 1．Neurotransmitter systems and function:
overview
1. Requirements:
1) Knowing the concept of neurotransmitter; the classification of neurotransmitters; the
structure and environment of neurons; the neurochemistry of neurotransmitters
2) Holding the basic action of neurotransmitters; the criteria of neurotransmitters
萨内
3) Understanding the mechanism of the action of neurotransmitters
生肖马今日运势2. Contents:
1) Chemical transmission
the concept of neurotransmitter; the process of chemical neurotransmission
2) Neurotransmitter classification
3) Neurons
structure and environment
4) Neurotransmitter function
basic circuitry; the excitatory action of neurotransmitters; the inhibitory action of
穷其一生neurotransmitters; the mechanism of the action of neurotransmitters;
neurotransmitter organization and utilization
境的成语5) Neurochemistry of neurotransmitters
the criteria of neurotransmitters; the prence, subcellular localization, synthesis, relea, receptors and degradation of neurotransmitters
3. Key words:
chemical transmission 化学传递
neurotransmitter 神经递质
neuron 神经元
dendrite 树突
axon 轴突
六年级下册数学手抄报soma 细胞体
synap 突触
axo-dentritic synap 轴突-树突突触
axo-axonic synap 轴突-轴突突触
axo-somatic synap 轴突-胞体突触
dendro-dendritic synap 树突-树突突触
excitatory postsynaptic potentials 兴奋性突触后电位
inhibitory postsynaptic potentials 抑制性突触后电位
asymmetric type 1 synap 非对称1型突触
symmetric type 2 synap 对称2型突触
neurotransmitter co-existence 神经递质共存
4． Questions:
1）What makes neurons special?
2）What are the features of neurotransmitters?
3）How does a signal move from one neuron to another?
4）What are the actions of neurotransmitters?
Chapter 2．Control of Neuronal Activity
1. Requirements:
1) Knowing the formation of ionic gradients, the role of pumps and the mechanism
underlying resting membrane potential; knowing the methods for recording ion channel currents and membrane potentials
2) Holding the features of ion channels and types of ion channels; holding types of
calcium channels, regulation of calcium channels by neurotransmitters and types of slow potassium channels.
3) Understanding the mechanism underlying action potentials; understanding the role
of slow potassium channels in adaptation and the role of calcium channels in plateau and pacemakin
g, the role of hyperpolarization-activated cation channels in pacemaking;
2. Contents:
心脏病的前兆1) The resting state of nerve cells
the formation of ionic gradients; the role of pumps; the mechanism underlying resting membrane potential
2) Ion channels
the features of ion channels；types of ion channels
3) Action potentials
the mechanism underlying action potentials
4) Calcium channels and transmitter relea
卤猪蹄子types of calcium channels；regulation of calcium channels by neurotransmitters
5) Ion channels affecting the pattern and frequency of action potential discharges
types of slow potassium channels; slow potassium channels and adaptation; calcium channels and plateau and pacemaking; hyperpolarization-activated cation channels and pacemaking
6) Recording neuronal activity
recording ion channel currents；single-channel and whole-cell current recording;
recording membrane potentials
3. Key words:
resting membrane potential 静息膜电位
action potential 动作电位
threshold 阈值
after-potential 后电位
after-hyperpolarization 负后电位
after-depolarization 正后电位
ion channels 离子通道
non-gating channels 非门控离子通道
gating channels 门控离子通道
patch clamp 膜片钳
voltage-gated sodium channels 电压门控钠通道
voltage-gated calcium channels 电压门控钙通道
delayed rectifier potassium channels 延迟整流钾通道
ionic gradients 离子递度
calcium-activated channels 钙激活的钾通道
inwardly-rectifying potassium channels
M-channels adaptation of action potentials
P/Q calcium channels
L calcium channels
T calcium channels
patch clamp
4． Questions:
1）What are the common features of ion channels?
刘备2）How many types of ion channels are there?
3）What are the roles of ion channels?
4）How are the pattern and frequency of action potential discharges regulated?
Chapter 3． Neurotransmitter receptors
1. Requirements:
1) Understand the structure, distribution and functional properties of
neurotransmitter receptors.
2) Holding the principles of how the action of drugs at neurotransmitter receptors
can be studied.
2.Contents:
1) Receptor conceptors
2). Chemical property
3). Function of receptors
4). Importance of receptors for the brain function
5). Identification and classification of neurotransmitter receptors
6) Receptor classification and mechanisms
Ion channel receptors
G-protein-coupled receptors
G-protein-coupled receptors densitization
3.Key words:
signaling 通讯，信号传（转）导
agonist 激动剂
antagonist 拮抗剂
ligand 配体
affinity 亲和力
radioligand binding technique 放射配体结合技术
patch-clamp 膜片钳
homology screening 同源性筛选
oligonucleotide 寡核苷酸
homogenization 匀浆
elution 洗提
