BALB/c
BALB/c mice
BALB/c is an albino, laboratory-bred strain of the Hou Mou from
which a number of common substrains are derived. Now over 200
generations from New York in 1920, BALB/c mice are distributed
globally, and are among the most widely ud inbred strains ud in
animal experimentation.[1]
History
Animal testing
Main articles
Animal testing
Alternatives to animal testing
Testing on: invertebrates
frogs · primates
rabbits · rodents
Animal testing regulations
History of animal testing
History of model organisms
IACUC
Laboratory animal sources
Pain and suffering in lab animals
Testing cosmetics on animals
Toxicology testing
Viviction
东山锦轩
Issues
Biomedical Rearch
Animal rights/Animal welfare
Animals (Scientific Procedures)
Great ape rearch ban
International trade in primates
斯莱普尼斯
Controversial experiments
Britches · Brown Dog affair
Cambridge University primates
Pit of despair
Silver Spring monkeys
带发的成语Unnecessary Fuss
Companies
Jackson Laboratory
Charles River Laboratories, Inc.
Covance ·Harlan
Huntingdon Life Sciences
UK lab animal suppliers
Nafovanny ·Shamrock
Groups/campaigns
AALAS ·AAAS ·ALF
绿蚂蚱
Americans for Medical Progress
Boyd Group ·BUAV
Dr Hadwen Trust
Foundation for Biomedical
Rearch ·FRAME
National Anti-Viviction Society
PETA ·Physicians Committee
for Responsible Medicine
Primate Freedom Project
Pro-Test
SPEAK ·SHAC
Speaking of Rearch
Understanding Animal Rearch
Writers/activists
Tipu Aziz ·Michael Balls
Neal Barnard ·Colin Blakemore
Simon Festing ·Gill Langley
Ingrid Newkirk ·Bernard Rollin
Jerry Vlasak ·Syed Ziaur Rahman
Categories
Animal testing ·Animal rights
Animal welfare
Related templates
otg是什么Template:Animal rights
微信聊天背景图片怎么设置The founding animals of the strain were obtained by Haly J. Bagg of Memorial Hospital, New York, from a mou dealer in Ohio in 1913. From 1920, the progeny of the original colony were systematically inbred, sibling to sibling, for 26 generations over 15 years. During this time, the colony pasd through the care of a number of scientists, including C.C. Little and E.C. MacDowell at the Carnegie Institution of Washington and H.J. Muller at the University of Texas.[2] By 1935 the animals were in the posssion of Muller's student, George Davis Snell, who moved them to The Jackson Laboratory. This stock provided the basis of all the BALB/c substrains that are now in u around the world.[3]
Snell provided some animals from this stock to the National Institutes of Health (NIH) to maintain. In 1961 D. W. Bailey ud some of the to generate a substrain at the University of California, San Fr
ancisco. In 1974, now 136 generations from the original breeding pair, the animals were returned to The Jackson Laboratory and were named BALB/cByJ.[3] On 16 November 2005, The Jackson Laboratory reported this substrain had reached its 235th generation.[4]
Snell also provided a colleague, J. Paul Scott, with some BALB/c breeding stock in 1938 or 1939.[2] When a fire destroyed the main Jackson Laboratory buildings in 1947,[5] all of Snell's original breeding stock perished, but Scott's mice were in a different building and survived. Scott donated stock back, at generation 41, to repopulate the colony. The progeny of the are now termed BALB/cJ and, as of 14 December 2006, were 221 generations from the founding stock.[6] Other less popular substrains, such as BALB/cWt, are maintained at the Jackson Laboratory, while the BALB/cN substrain is maintained by the NIH.[3]
Characteristics
BALB/c mice are uful for rearch into both cancer and immunology. According to Michael Festing's Inbred Strains of Mice,[1] BALB/c substrains are "particularly well known for the production of plasmacytomas on injection with mineral oil," an important process for the production of monoclonal antibodies. They are also reported as having a "low mammary tumour incidence,[1] but
do develop other types of cancers in later life, most commonly reticular neoplasms, lung tumours, and renal tumours.[4][6] Most substrains have a "long reproductive life-span",[1] are noted for displaying high levels of anxiety and for being relatively resistant to diet-induced atherosclerosis, making them a uful model for cardiovascular rearch.[4][6]
There are noted differences between different BALB/c substrains, though the are thought to be due to mutation rather than genetic contamination.[7] For example, male BALB/c mice are aggressive and will fight other males if houd together. However, the BALB/Lac substrain is much more docile.[8] The BALB/cWt is also unusual in that 3% of progeny display true hermaphroditism.[9]
External links
•Jackson Laboratory's mou strains [10]
References
[1]"BALB/c" (www.informatics.jax/external/festing/mou/docs/BALB.shtml). Inbred Strains of Mice. Jackson Laboratory. .
Retrieved 2007-04-16.
[2]Potter M. History of the BALB/c family, pp 1-5. In: The BALB/c Mou: Genetics and Immunology, Current Topics in Microbiology and
Immunology, Vol. 122. Springer-Verlag, NY. 1985.
[3]"A Brief History of the Two Substrains of BALB/c, BALB/cJ, and BALB/cByJ" (jaxmice.jax/jaxnotes/archive/443a.html). Jax
Mice Literature. Jackson Laboratory. . Retrieved 2010-09-30.
[4]"BALB/cByJ" (web.archive/web/20061116054205/jaxmice.jax/strain/001026_2.html). Jax Mice Data Sheet.
Jackson Laboratory. Archived from the original (jaxmice.jax/strain/001026_2.html) on 16 November 2006. . Retrieved
2007-04-16.
[5]"The Jackson Laboratory Milestones: 1940 - 1949" (web.archive/web/20070915090022/www.jax/about/timeline/
1940.html). The Jackson Laboratory Timeline. Jackson Laboratory. Archived from the original (www.jax/about/timeline/1940.
取笑的反义词是什么html) on 15 September 2007. . Retrieved 2007-04-16.
[6]"BALB/cJ" (jaxmice.jax/strain/000651.html). Jax Mice Data Sheet. Jackson Laboratory. Archived (web.archive/
web/20070411205957/jaxmice.jax/strain/000651.html) from the original on 11 April 2007. . Retrieved 2007-04-16.
[7]Hilgers J., van Nie R., Ivanyi D., Hilkens J., Michalides R., de Moes J., Poort-Keesom R., Kroezen V., von Deimling O., Kominami R., and
Holmes R. (1985) Genetic differences in BALB/c sublines. Curr. Top. Microbiol. Immunol. 122, 19-30.
[8]Southwick C. H. and Clark L. H. (1966) Aggressive behaviour and exploratory activity in fourteen mou strains. Am. Zool. 6, 559.
[9]Eicher E. M., Beamer W. G., Washburn L. L., and Whitten W. K. (1980) A cytogenetic investigation of inherited true hermaphroditism in
BALB/cWt mice. Cytogenet. Cell Genet. 28, 104-115.
[10]jaxmice.jax/newstrains/index.html
Article Sources and Contributors4 Article Sources and Contributors
张字书法
BALB/c Source: en.wikipedia/w/index.php?oldid=523549386 Contributors: Amcl, Axl, Daniel Mietchen, Jodyc, MER-C, Mparu, Rich Farmbrough, Rockpocket, SMcCandlish,
SlimVirgin, Squidonius, Stemonitis, 7 anonymous edits
Image Sources, Licens and Contributors
Image:Lightmatter lab mice.jpg Source: en.wikipedia/w/index.php?title=File:Lightmatter_lab_mice.jpg Licen: Creative Commons Attribution Contributors: by Aaron Logan
Image:Wistar rat.jpg Source: en.wikipedia/w/index.php?title=File:Wistar_rat.jpg Licen: Public Domain Contributors: Janet Stephens (photographer)
Licen
Creative Commons Attribution-Share Alike 3.0 Unported
//creativecommons/licens/by-sa/3.0/
