SB203580_p38MAPK抑制剂_说明书
SB203580 (p38 MAPK抑制剂)
产品简介：
SB203580也写作SB 203580或SB-203580，是一种常用的p38 MAPK抑制剂。SB203580可以通透细胞，抑制p38 MAPK (p38 MAP kina)，抑制后续MAPKAP Kina-2和MAPKAP Kina-3的激活。通过抑制p38 MAPK，SB203580可以有效抑制一些炎症因子(如IL-1β、TNF-α)诱导的部分信号转导。SB203580选择性抑制p38 MAPK，IC50为600 n M；对于JNK/SAPK和p44/42 MAPK (即Erk1/2)无显著的抑制作用，IC50仅为100 μM。
SB203580分子量为377.43，分子式为C21H16N3FOS，CAS Number：152121-47-6。本产品纯度大于99%。
17岁正常身高本SB203580为进口分装，用DMSO配制，浓度为20mg/ml，共50μl。
保存条件：
-20℃避光保存，一年有效。
注意事项：
SB203580对人体有刺激性，请注意适当防护。
网络短信>工程进度表模板
本SB203580在4℃、冰浴等较低温度情况下会凝固而粘在离心管管底、管壁或管盖内，可以20-25℃水浴温育片刻至全部融解后使用。
为了您的安全和健康，请穿实验服并戴一次性手套操作。
使用说明：
1.SB203580常见使用浓度范围为1-50μM。具体的最佳工作浓度请参考相关文献，或根据实验目的，以及所培养的特定细
胞和组织，通过实验进行摸索和优化。
使用本产品的文献：
1. Shi X, Zhou B.
The role of Nrf2 and MAPK pathways in PFOS-induced oxidative stress in zebrafish embryos.
Toxicol Sci. 2010;115(2):391-400. Epub 2010 Mar 3.
2. Jiang Z, Li S, Liu Y, Deng P, Huang J, He G.
是你的歌词Sesamin induces melanogenesis by microphthalmia-associated transcription factor and tyrosinaup-regulation via cAMP signaling pathway.
Acta Biochim Biophys Sin (Shanghai). 2011 Oct;43(10):763-70.
3. Jin W, Li Q, Lin Y, Lu Y, Li H, Wang L, Hu R, Ma L, Wang J, Pang T.
四冲程内燃机
Reversal of Imatinib resistance in BCR-ABL-positive leukemia after inhibition of the Na+/H+exchanger.
Cancer Lett. 2011 Sep 1;308(1):81-90.
4. Gong J, Shen XH, Chen C, Qiu H, Yang RG.
Down-regulation of HIV-1 infection by inhibition of the MAPK signaling pathway.
Virol Sin. 2011 Apr;26(2):114-22.
5. Lin M, Wang X, Zhu J, Fan D, Zhang Y, Zhang J, Guo Z.
Cellular and biomolecular respons of human ovarian cancer cells to cytostatic dinuclearplatinum(II) complexes.
Apoptosis. 2011 Mar;16(3):288-300.
6. Fang S, Jin Y, Zheng H, Yan J, Cui Y, Bi H, Jia H, Zhang H, Wang Y, Na L, Gao X, Zhou H.
High gluco condition upregulated Txnip expression level in rat mesangial cells throughROS/MEK/MAPK pathway.
Mol Cell Biochem. 2011 Jan;347(1-2):175-82.
7. Li W, Liu Y, Li XX, Yu Y, Wu JJ, Wang Q, Huo H, Wang LM, Yang L.
MAPKs are not involved in triptolide-induced cell growth inhibition and apoptosis in prostate cancer cell lines with different p53 status.
Planta Med. 2011 Jan;77(1):27-31.
8. Feng J, Zhang P, Chen X, He G.
PI3K and ERK/Nrf2 pathways are involved in oleanolic acid-induced heme oxygena-1 expressionin rat vascular smooth muscle cells.
J Cell Biochem. 2011 Jun;112(6):1524-31.
学会面对
9. Sun C, Wang L, Yan J, Liu S.
Calcium ameliorates obesity induced by high-fat diet and its potential correlation with p38 MAPKpathway.
Mol Biol Rep. 2012 Feb;39(2):1755-63.
10.Zhu F, Shen F, Fan Y, Xie Y, Xia Y, Kong Y
Osteopontin increas the expression of β1, 4-Galactosyltransfera-I and promotes adhesion inhuman RL95-2 cells.
Glycoconj J. 2012 Jul 31.
11.Wang LH, Chang GQ, Zhang HJ, Wang J, Lin YN, Jin WN, Li HW, Gao W, Wang RJ, Li QH, Pang TX.
Neutrophil gelatina-associated lipocalin regulates intracellular accumulation of Rh123 in cancercells.
Genes Cells. 2012 Mar;17(3):205-17.
12.Guo C, Yuan H, He Z.
右姓Melamine caus apoptosis of rat kidney epithelial cell line (NRK-52e cells) via excessiveintracellular ROS (reactive oxygen species) and the activation of p38 MAPK pathway.
Cell Biol Int. 2012 Apr 1;36(4):383-9.
13.Sun C, Qi R, Wang L, Yan J, Wang Y
p38 MAPK regulates calcium signal-mediated lipid accumulation through changing VDRexpression in primary preadipocytes of mice.
Mol Biol Rep. 2012 Mar;39(3):3179-84.
带来英文
14.Teng M, Jiang XP, Zhang Q, Zhang JP, Zhang DX, Liang GP, Huang YS.
Microtubular stability affects pVHL-mediated regulation of HIF-1alpha via the p38/MAPK pathway inhypoxic cardiomyocytes.
PLoS One. 2012;7(4):e35017.
15.Zhong Y, Liu T, Guo Z.
Curcumin inhibits ox-LDL-induced MCP-1 expression by suppressing the p38MAPK and NF-κBpathways in rat vascular smooth muscle cells.
Inflamm Res. 2012 Jan;61(1):61-7.
