Bioengineered viral vectors for targeting and kill

更新时间:2023-06-02 08:20:57 阅读: 评论:0

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Bioengineered viral vectors for targeting and killing潍坊风筝广场
震旦鸦雀prostate cancer cells.
期刊名称: Bioengineered bugs
作者: Kai-xin Zhang,William Jia,Paul S Rennie
年份: 2010年
石崇期号: 第2期
关键词: Cell Line, Tumor;Animals;Humans;Lentivirus;Prostatic Neoplasms;Gene
Targeting;Genetic Engineering;Gene Expression Regulation, Viral;Genetic
Vectors;Male开根号函数
摘要:Enabling the transduction of therapeutic gene expression exclusively in diad sites is the key 真知灼见什么意思
人人为我to developing more effective treatments for advanced prostate cancer using viral-bad therapy. While prostate cancers that express high levels of HER 2 are resistant to the killing effects of trastuzumab, they can be targeted for lective gene expression and destruction by lentivirus with envelope proteins engineered to bind to this therapeutic antibody. More importantly, after intravenous injection, this trastuzumab-bound lentivirus is able to target castration-resistant prostate tumour xenografts, albeit with low efficiency. This proof of principle opens up multiple possibilities for the prevention and treatment of prostate cancer using a viral-bad therapy. However, to be safe and more effective, the viral vectors
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