献血的意义
Cancer immunotherapy with mRNA-transfected
dendritic cells
儿童止咳期刊名称： Immunological Reviews
好逸恶劳
作者： Eli Gilboa,Johannes Vieweg
作者机构： Department of Surgery and
年份： 2010年
期号： 第1期
本科毕业论文模板我向往的地方关键词： Humans;Dendritic Cells;CD4-Positive T-Lymphocytes;T-Lymphocytes, Cytotoxic;Prostate-Specific Antigen;Immunotherapy;Antigens,
Neoplasm;Transfection;Neoplasms;RNA, Mesnger
饮料瓶手工工地宣传标语
摘要：Bone marrow-derived dendritic cells (DCs) are the most potent antigen-prenting cells capable of activating nave T cells. Loading DCs ex vivo with tumor antigens can stimulate potent antitumor immunity in tumor-bearing mice. This review describes the u of mRNA-encoded tumor antigens as a form of antigen loaded onto DCs, including our early experience from clinical trials in urological cancers. Transfection of DCs with mRNA is simple and effective. Comparative studies suggest that mRNA transfection is superior to other antigen-loading techniques in generating immunopotent DCs. The ability to amplify RNA from microscopic amounts of tumor tissue extends the u of DC vaccination to virtually every cancer patient. The striking obrvation from two pha I clinical trials, in patients with prostate cancer immunized
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