大唐荣耀剧情介绍>薰衣草精油的作用
灭害虫春节短文30字>茶花怎么养Metabolism and excretion of citalopram in man: identification of O-acyl- and N-glucuronides 期刊名称： Xenobiotica
作者： Dalgaard, L., Larn, C.
年份： 1999年
期号： 第10期
关键词： Humans;Citalopram;Glucuronides;Serotonin Uptake
Inhibitors;Acylation;Mass Spectrometry;Adult;Chromatography, High Pressure Liquid;Chromatography, Liquid;Male
励志电视剧排行榜前十名摘要：1. The antidepressant citalopram (CT), a lective rotonin uptake inhibitor, was given in its labelled form, [14C]-CT, as a single oral do in 50 ml aqueous solution (0.1 mmol/30 Ci/1.1 MBq) to four healthy male volunteers. 2. Concentrations of radioactivity in whole blood and plasma were similar. The respective pharmacokinetic parameters were: Cmax=214±41 and 246±69 nmol eq./litre, Tmax=3 a
nd 2 h, AUC=18289±2959 and 14537±2883 nmol eq.h/litre, and t1/2=90.2±22.5 and 79.5±14.9 h respectively. A mean of 85.2±10.4% of the radioactive do was recovered after 17 days of collection of excreta. The majority of radioactivity was excreted in urine (74.7±8.9%) and the remaining part in faeces (10.5±2.3%). 3. The HPLC profile of urinary components showed that besides the known metabolites of citalopram, three glucuronides
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